Flubendiamide induces transgenerational compound eye alterations in Drosophila melanogaster

Sarkar, Saurabh; Roy, Sumedha

doi:10.1515/intox-2017-0020

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…The effects of flubendiamide on the ocular surface were studied in non-target Drosophila melanogaster to evaluate cross-reactivity in species at which the insecticide is not directed. It was found that flubendiamide altered the compound eye architecture and bristle pattern orientation in four generations of non-target D. melanogaster at doses consistent with those administered in fields in India [ 146 , 147 ]. The irritative nature of flubendiamide is further explored in a report published by the Food Safety Commission of Japan, as the insecticide was linked to ocular inflammation in rats [ 148 ].…”

Section: Pesticide Exposurementioning

confidence: 99%

Toxic External Exposure Leading to Ocular Surface Injury

Rauchman

Locke

Albert

et al. 2023

Vision

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The surface of the eye is directly exposed to the external environment, protected only by a thin tear film, and may therefore be damaged by contact with ambient particulate matter, liquids, aerosols, or vapors. In the workplace or home, the eye is subject to accidental or incidental exposure to cleaning products and pesticides. Organic matter may enter the eye and cause infection. Ocular surface damage can trigger a range of symptoms such as itch, discharge, hyperemia, photophobia, blurred vision, and foreign body sensation. Toxin exposure can be assessed clinically in multiple ways, including via measurement of tear production, slit-lamp examination, corneal staining, and conjunctival staining. At the cellular level, environmental toxins can cause oxidative damage, apoptosis of corneal and conjunctival cells, cell senescence, and impaired motility. Outcomes range from transient and reversible with complete healing to severe and sight-compromising structural changes. Classically, evaluation of tolerance and safety was carried out using live animal testing; however, new in vitro and computer-based, in silico modes are superseding the gold standard Draize test. This review examines how environmental features such as pollutants, temperature, and seasonality affect the ocular surface. Chemical burns to the eye are considered, and approaches to protect the ocular surface are detailed.

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Section: Pesticide Exposurementioning

confidence: 99%

Toxic External Exposure Leading to Ocular Surface Injury

Rauchman

Locke

Albert

et al. 2023

Vision

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Flubendiamide affects visual and locomotory activities of Drosophila melanogaster for three successive generations (P, F1 and F2)

Sarkar

Roy

2018

Invert Neurosci

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Flubendiamide is widely used in agricultural fields to exterminate a broad spectrum of pests (lepidopteran insects) by disrupting their muscle function. The main objective of this study was to find the effects of flubendiamide on a non-target organism, Drosophila melanogaster (dipteran insect). In the present study, different sub-lethal concentrations of Flubendiamide caused a significant (P < 0.05) decrease in acetylcholinesterase activity and increase in cytochrome P450 activity in adult D. melanogaster. Phototaxis and climbing behaviours were found to significantly (P < 0.05) alter in exposed flies. The observed alteration in phototaxis and climbing behaviours were not restricted to P generation, but were found to be transmitted to subsequent generations (F and F generation) that had never been directly exposed to the test chemical during their life time. It is only their predecessors (P generation) who have been affronted with different concentrations of Flubendiamide. Humans and Drosophilids share almost 60% genomic similarity and 75% disease gene resemblance. Moreover, most of the circuits governing the behaviours studied involve the inhibition and excitation of neurotransmitters, which are conserved in humans and flies. Thus, the present findings suggest that chronic flubendiamide exposure might induce alteration in neurotransmission leading to discrepancy in the behavioural responses (vision and flight) in other beneficial insects and insect-dependent organisms.

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