Fluconazole and selective digestive decontamination for prevention of Candida infection in high risk critically ill patients

Beshey, Bassem Nashaat; Okasha, A; Eldin, Mahmoud Elsayed Nour

doi:10.1016/j.ajme.2013.06.002

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Fluconazole is a triazole antifungal agent that is clinically widely used due to its advantages of excellent bioavailability and low toxicity [ 23 ]. Fluconazole was added into organic phase solution to prepare micelles with their hydrophobic cores loaded with the drug.…”

Section: Resultsmentioning

confidence: 99%

Production of Fluconazole-Loaded Polymeric Micelles Using Membrane and Microfluidic Dispersion Devices

Chowdhury

Vladisavljević

et al. 2016

Membranes

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Polymeric micelles with a controlled size in the range between 41 and 80 nm were prepared by injecting the organic phase through a microengineered nickel membrane or a tapered-end glass capillary into an aqueous phase. The organic phase was composed of 1 mg·mL−1 of PEG-b-PCL diblock copolymers with variable molecular weights, dissolved in tetrahydrofuran (THF) or acetone. The pore size of the membrane was 20 μm and the aqueous/organic phase volumetric flow rate ratio ranged from 1.5 to 10. Block copolymers were successfully synthesized with Mn ranging from ~9700 to 16,000 g·mol−1 and polymeric micelles were successfully produced from both devices. Micelles produced from the membrane device were smaller than those produced from the microfluidic device, due to the much smaller pore size compared with the orifice size in a co-flow device. The micelles were found to be relatively stable in terms of their size with an initial decrease in size attributed to evaporation of residual solvent rather than their structural disintegration. Fluconazole was loaded into the cores of micelles by injecting the organic phase composed of 0.5–2.5 mg·mL−1 fluconazole and 1.5 mg·mL−1 copolymer. The size of the drug-loaded micelles was found to be significantly larger than the size of empty micelles.

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Section: Resultsmentioning

confidence: 99%

Production of Fluconazole-Loaded Polymeric Micelles Using Membrane and Microfluidic Dispersion Devices

Chowdhury

Vladisavljević

et al. 2016

Membranes

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show abstract

“…have risen considerably in recent years and represent a crescent global health problem (G acser et al 2014). The increase of infections like mucosal and systemic candidiasis can be explained by a high number of patients at risk, like as the possibility of these yeasts to invade unharmed tissues (Beshey et al 2013). Patients are receiving chemotherapy; transplant recipients and diabetics are more susceptible to fungal infections because they are with their impaired immunity (Kathiravan et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Reversal of fluconazole resistance induced by a synergistic effect withAcca sellowianainCandida glabratastrains

Machado

Pippi

Lana

et al. 2016

Pharmaceutical Biology

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Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation

Pifferi

Brazzi

Pecoraro

et al. 2021

Cochrane Database of Systematic Reviews

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Fluconazole and selective digestive decontamination for prevention of Candida infection in high risk critically ill patients

Cited by 7 publications

References 20 publications

Production of Fluconazole-Loaded Polymeric Micelles Using Membrane and Microfluidic Dispersion Devices

Production of Fluconazole-Loaded Polymeric Micelles Using Membrane and Microfluidic Dispersion Devices

Reversal of fluconazole resistance induced by a synergistic effect withAcca sellowianainCandida glabratastrains

Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation

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