2011
DOI: 10.1016/j.jaci.2011.03.010
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Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children

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Cited by 70 publications
(63 citation statements)
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“…Our new findings indicate that the daily fluctuation and the diurnal variation of FeNO provided more information regarding the control of asthma and the future risk of exacerbation. Our data is in agreement with recent studies reporting that monitoring of FeNO revealed changes in FeNO prior to the onset of moderate exacerbations [32], and that analysis of the fluctuation of daily FeNO provided useful information on asthma control [17].…”
Section: Discussionsupporting
confidence: 93%
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“…Our new findings indicate that the daily fluctuation and the diurnal variation of FeNO provided more information regarding the control of asthma and the future risk of exacerbation. Our data is in agreement with recent studies reporting that monitoring of FeNO revealed changes in FeNO prior to the onset of moderate exacerbations [32], and that analysis of the fluctuation of daily FeNO provided useful information on asthma control [17].…”
Section: Discussionsupporting
confidence: 93%
“…However, several studies have shown its limitation in monitoring asthma therapy [28][29][30]. Support for a greater usefulness of daily FeNO measurements has recently been obtained [17,18,31,32]. In the current study, a single measurement of FeNO correlated well with FEV1 % pred and with percentage of sputum eosinophils, indicating that FeNO reflected both the inflammatory component as well as airflow obstruction.…”
Section: Discussionsupporting
confidence: 71%
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“…Higher FeNO values, perhaps due to the higher reported inducible nitric oxide synthase expression in severe asthmatic epithelial cells, have been associated with a more exacerbation prone phenotype in severe asthma, as well as more rapid decline in FEV1 [76,[91][92][93]. In addition, higher levels of oxidative stress have been associated with a reduction in superoxide dismutase and s-nitrosothiol depletion [94,95].…”
Section: Activation Of Innate Immune Pathwaysmentioning
confidence: 99%
“…Moreover, alveolar NO is more sensitive to oral than to inhaled corticosteroids, suggesting that it may represent true abnormalities of peripheral airways, which are better reached by systemic drugs than by conventional inhaled formulations [20]. More recently, a method of monitoring the daily fluctuations in FeNO values with quantification over a period of time has been established, providing information on a subject's asthma severity with regard to asthma control and exacerbation risk [53].…”
Section: Biological Assessment Of Peripheral Airwaysmentioning
confidence: 99%