Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia

How I treat LGL leukemia

“…12,65,69,[76][77][78][79][80][81][82] The overall ORR indicates overall response rate; CHR, complete hematologic response; -, not applicable; PRCA, pure red cell aplasia; and CR, complete response. *A total of 50-100 mg/day or 250-500 mg intravenously.…”

T-cell large granular lymphocytic (T-LGL) leukemia: a single institution experience

“…Because of the rarity of T-LGL leukemia, very few prospective clinical trials have been reported, and current treatment strategies are based on anecdotal case reports and small retrospective studies. In previous reports, treatment with immunomodulation, corticosteroids, low-dose methotrexate, cyclophosphamide, and cyclosporine A with or without purine analogues are all described [2,[9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

“…Tse et al [13] reported results using Fludarabine in patients with T-LGL leukemia. Two patients received Fludarabine with Mitoxantrone and Dexamethasone (FND) while one patient received this therapy without Mitoxantrone.…”

Białaczki z dużych ziarnistych limfocytów T i komórek naturalnej cytotoksyczności

“…Uzyskane remisje są długotrwałe, nawet kilkuletnie. Należy jednak pamiętać, że opublikowane prace dotyczą kilku chorych, dlatego są konieczne prospektywne badania kliniczne, w których zostanie ocenione zastosowanie analogów puryn u większej liczby chorych [41,[74][75][76][77].…”