Fluid balance and chloride load in the first 24 h of ICU admission and its relation with renal replacement therapies through a multicentre, retrospective, case–control study paired by APACHE-II

González-Castro, A.; Ortiz-Lasa, María; Leizaola, O.; Salgado, E.; Irriguible, T.M. Tomasa; Sánchez-Satorra, M.; Lomas-Fernández, C.; Barral-Segade, P.; Cordero-Vallejo, M.; Rodrigo-Calabia, Emilio; Dierssen-Sotos, Trinidad

doi:10.1016/j.redare.2016.12.002

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…FO is defined as cumulative fluid balance (FB) greater than 10% of body weight [ 10 , 11 ]. Positive cumulative FB has been reported in up to 40% of patients admitted to the ICU [ 12 ]; Moreover, several studies have shown that a persistent cumulative positive FB negatively impacts ICU patient outcomes [ 2 , 13 ]. In patients with acute lung injury, positive FB was associated with further impaired oxygenation and prolonged need for mechanical ventilation [ 11 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Percent fluid overload for prediction of fluid de-escalation in critically ill patients in Saudi Arabia: a prospective observational study

Alharbi

Aldardeer²,

Heaphy

et al. 2023

ACC

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Background: Percent fluid overload greater than 5% is associated with increased mortality. The appropriate time for fluid deresuscitation depends on the patient's radiological and clinical findings. This study aimed to assess the applicability of percent fluid overload calculations for evaluating the need for fluid deresuscitation in critically ill patients. Methods: This was a single-center, prospective, observational study of critically ill adult patients requiring intravenous fluid administration. The study's primary outcome was median percent fluid accumulation on the day of fluid deresuscitation or intensive care unit (ICU) discharge, whichever came first. Results: A total of 388 patients was screened between August 1, 2021, and April 30, 2022. Of these, 100 with a mean age of 59.8±16.2 years were included for analysis. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 15.4±8.0. Sixty-one patients (61.0%) required fluid deresuscitation during their ICU stay, while 39 (39.0%) did not. Median percent fluid accumulation on the day of deresuscitation or ICU discharge was 4.5% (interquartile range [IQR], 1.7%–9.1%) and 5.2% (IQR, 2.9%–7.7%) in patients requiring deresuscitation and those who did not, respectively. Hospital mortality occurred in 25 (40.9%) of patients with deresuscitation and six (15.3%) patients who did not require it (P=0.007). Conclusions: The percent fluid accumulation on the day of fluid deresuscitation or ICU discharge was not statistically different between patients who required fluid deresuscitation and those who did not. A larger sample size is needed to confirm these findings.

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Section: Introductionmentioning

confidence: 99%

“…The term deresuscitation or de-escalation was first suggested in 2012, and finally coined in the literature in 2014 [ 13 ]. Deresuscitation or de-escalation refers to the phase of critical illness after initial resuscitation, stabilization, and optimization [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Percent fluid overload for prediction of fluid de-escalation in critically ill patients in Saudi Arabia: a prospective observational study

Alharbi

Aldardeer²,

Heaphy

et al. 2023

ACC

View full text Add to dashboard Cite

show abstract

“…FO is de ned as cumulative uid balance (FB) of more than 10% of body weight (10,11). Positive cumulative FB was reported in up to 40% of patients admitted to the ICU (12); Moreover, several studies have shown that a persistent cumulative positive uid balance negatively impacts ICU patients' outcomes (2,13). In patients with acute lung injury, positive FB was associated with further impaired oxygenation and prolonged need for mechanical ventilation (11,14).…”

Section: Introductionmentioning

confidence: 99%

“…The term de-resuscitation or de-escalation was rst suggested in 2012 and nally coined in 2014 (13). It refers explicitly to 'Late Goal-Directed Fluid Removal,' which involves "aggressive and active uid removal through diuretics and renal replacement therapy with net ultra ltration."…”

Section: Introductionmentioning

confidence: 99%

Percent Fluid Overload for the Prediction of the Need for Fluid De-resuscitation in Critically Ill Patients: A Single-Centre Prospective Cohort Study

Alharbi

Aldardeer

Heaphy

et al. 2022

Preprint

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Background: Positive fluid balance (FB) was reported in up to 40% of patients admitted to the ICU. Many studies found that positive FB is associated with increased mortality. The appropriate time for fluid de-resuscitation (DER) is controversial. This study aims to evaluate the association between percent fluid overload calculation and the need for fluid de-resuscitation among critically ill adult patients. Methods: A Prospective observational study was conducted at a single-center tertiary care hospital. The study included adult critically ill patients requiring intravenous fluid administration. Patients who were de-resuscitated with diuretics and/or renal replacement therapy were compared to those who did not require de-resuscitation. The study compared both groups for the median percent fluid accumulation on the day of fluid de-resuscitation or ICU discharge, whatever comes first. Results: Three hundred eighty-eight patients were screened between August 01, 2021, and April 30, 2022. One hundred patients were included with a mean age of 59.8 ± 16.2. The mean APACHE II score was 15.4 ±8.0. Sixty-one patients (61%) required fluid de-resuscitation, while 39 (39%) patients didn't require fluid de-resuscitation during ICU stay. Median percent fluid accumulation on the day of de-resuscitation or ICU discharge was 3.8% (1.2-8.6) and 5.3% (2.7-8.6) in patients requiring de-resuscitation and those who did not, respectively (P-value NS). Hospital mortality was found in 25 (40.9%) patients with de-resuscitation and 6 (15.3%) in those who did not require it; (P-value 0.0069). Conclusions: The median percent fluid accumulation on the day of fluid de-resuscitation or ICU discharge was not statistically different between patients who required fluid de-resuscitation and those who did not. A larger sample size is needed to confirm these findings.

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Meta-analysis of the effects of normal saline on mortality in intensive care

González-Castro

Ortiz-Lasa

Rodríguez-Borregán

et al. 2019

Revista Española de Anestesiología y Reanimación (English Editi

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Fluid balance and chloride load in the first 24 h of ICU admission and its relation with renal replacement therapies through a multicentre, retrospective, case–control study paired by APACHE-II

Cited by 3 publications

References 18 publications

Percent fluid overload for prediction of fluid de-escalation in critically ill patients in Saudi Arabia: a prospective observational study

Percent fluid overload for prediction of fluid de-escalation in critically ill patients in Saudi Arabia: a prospective observational study

Percent Fluid Overload for the Prediction of the Need for Fluid De-resuscitation in Critically Ill Patients: A Single-Centre Prospective Cohort Study

Meta-analysis of the effects of normal saline on mortality in intensive care

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