Fluid Circuit Technology:  Integrated Interconnect Technology for Miniature Fluidic Devices

VerLee, D.; Alcock, A. J.; Clark, Gregory A.; Huang, Teng-Chieh; Kantor, Stanislaw; Nemcek, T.; Norlie, J.; Pan, Jhih-Yuan; Walsworth, F.; Wong, Sing

doi:10.31438/trf.hh1996.3

Cited by 14 publications

(4 citation statements)

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“…Industrial interest in utilizing plastics for the production of microanalytical systems is primarily driven by the fact that these materials are less expensive and easier to manipulate than silica-based substrates. Plastics lend themselves readily to casting, molding, laser ablation, and machining operations . A wide variety of low-cost polymer materials enable selection for thermal and chemical resistance, molding temperature, and surface derivatization properties.…”

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confidence: 99%

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Fabrication of Plastic Microfluid Channels by Imprinting Methods

et al. 1997

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Microfluidic devices have been fabricated on poly(methyl methacrylate) substrates by two independent imprinting techniques. First-generation devices were fabricated using a small-diameter wire to create an impression in plastics softened by low-temperature heating. The resulting devices are limited to only simple linear channel designs but are readily produced at low cost. Second-generation devices with more complex microchannel arrangements were fabricated by imprinting the plastic substrates using an inverse three-dimensional image of the device micromachined on a silicon wafer. This micromachined template may be used repeatedly to generate devices reproducibly. Fluorescent analtyes were used to demonstrate reproducible electrophoretic injections. An immunoassay was also performed in an imprinted device as a demonstration of future applications.

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“…Plastics lend themselves readily to casting, molding, 21 laser ablation, 22 and machining operations. 23 A wide variety of low-cost polymer materials enable selection for thermal and chemical resistance, molding temperature, and surface derivatization properties. In this report, we describe two methods for imprinting microchannels in plastic substrates.…”

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Fabrication of Plastic Microfluid Channels by Imprinting Methods

et al. 1997

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“…The first attempts at fabricating microchannels in plastic, which used a computer-controlled milling machine, were only capable of fairly large features (approximately 800 μm), which led to undesired turbulent flow [2]. Advances in technology permitted the fabrication of much smaller diameters.…”

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confidence: 99%

Deep-UV patterning of commercial grade PMMA for low-cost, large-scale microfluidics

Haiducu

Rahbar

Foulds

et al. 2008

J. Micromech. Microeng.

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Although PMMA can be exposed using a variety of exposure sources, deep-UV at 254 nm is of interest because it is relatively inexpensive. Additionally, deep-UV sources can be readily scaled to large area exposures. Moreover, this paper will show that depths of over 100 μm can be created in commercial grade PMMA using an uncollimated source. These depths are sufficient for creating microfluidic channels. This paper will provide measurements of the dissolution depth of commercial grade PMMA as a function of the exposure dose and etch time, using an IPA:H 2 O developer. Additionally, experiments were run to characterize the dependence of the dissolution rate on temperature and agitation. The patterned substrates were thermally bonded to blank PMMA pieces to enclose the channels and ports were drilled into the reservoirs. The resulting fluidic systems were then tested for leakage. The work herein presents the patterning, development and system behaviour of a complete microfluidics system based on commercial grade PMMA.

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“…The need for intermediate-scale fluid-handling systems has been identified . Among the developments in this area are pneumatic diaphragm valves integrated directly into the device's fluidics channels.…”

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Fluidics Cube for Biosensor Miniaturization

et al. 2001

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To create a small, portable, fully automated biosensor, a compact means of fluid handling is required. We designed, manufactured, and tested a "fluidics cube" for such a purpose. This cube, made of thermoplastic, contains reservoirs and channels for liquid samples and reagents and operates without the use of any internal valves or meters; it is a passive fluid circuit that relies on pressure relief vents to control fluid movement. We demonstrate the ability of pressure relief vents to control fluid movement and show how to simply manufacture or modify the cube. Combined with the planar array biosensor developed at the Naval Research Laboratory, it brings us one step closer to realizing our goal of a handheld biosensor capable of analyzing multiple samples for multiple analytes.

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Fluid Circuit Technology: Integrated Interconnect Technology for Miniature Fluidic Devices

Cited by 14 publications

References 0 publications

Fabrication of Plastic Microfluid Channels by Imprinting Methods

Fabrication of Plastic Microfluid Channels by Imprinting Methods

Deep-UV patterning of commercial grade PMMA for low-cost, large-scale microfluidics

Fluidics Cube for Biosensor Miniaturization

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