Fluid-Structure Interaction in Coronary Stents: a Discrete Multiphysics Approach

Mohammed, Aminu; Ariane, Mostapha; Alexiadis, Alessio

doi:10.20944/preprints202106.0733.v1

2021

DOI: 10.20944/preprints202106.0733.v1

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Fluid-Structure Interaction in Coronary Stents: a Discrete Multiphysics Approach

Aminu Mohammed¹,

Mostapha Ariane²,

Alessio Alexiadis³

Abstract: Stenting is a common method for treating atherosclerosis. A metal or polymer stent is deployed to open the stenosed artery or vein. After the stent is deployed, the blood flow dynamics influence the mechanics by compressing and expanding the structure. If the stent does not respond properly to the resulting stress, vascular wall injury or re-stenosis can occur. In this work, Discrete Multiphysics is used to study the mechanical deformation of the coronary stent and its relationship with the blood flow dynamics… Show more

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Cited by 3 publications

References 47 publications

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Finite Element Analysis of Fluid–Structure Interaction in a Model of an L-Type Mg Alloy Stent-Stenosed Coronary Artery System

Chen

Yang

Wang

et al. 2022

Metals

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The coronary stent deployment and subsequent service process is a complex geometric/physical nonlinear and fluid–structure coupling system. Analyzing the distribution of stress–strain on the stent is of great significance in studying the deformation and failure behavior. A coupled system dynamics model comprising stenotic coronary artery vessels and L-type Mg alloy stents was established by applying the polynomial hyperelastic constitutive theory. The nonlinear, significant deformation behavior of the stent was systematically studied. The stress–strain distribution of the coupling system during stent deployment was analyzed. The simulation results show that the edges of the supporting body fixed without a bridge are the weakest zone. The stress changes on the inside of the wave of the supporting body are very large, and the residual stress accumulated in this area is the highest. The peak stress of the plaque and the arterial wall was lower than the damage threshold. The velocity of the blood between the wave crest of the supporting body is large and the streamline distribution is concentrated. In addition, the inner surface pressure on the stent is evenly distributed along its axial dimension. The maximum arterial wall shear stress always appears on the inside of the wave crest of the supporting body fixed with a bridge, and, as such, the largest obstacle to the blood flow is in this zone.

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Finite Element Analysis of Fluid–Structure Interaction in a Model of an L-Type Mg Alloy Stent-Stenosed Coronary Artery System

Chen

Yang

Wang

et al. 2022

Metals

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show abstract

Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model

et al. 2022

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The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade flows of 0.06–0.78 cm s−1 and backflows of −2.16–−0.21 cm s−1 were measured. Mean wall shear rates were strongly time and viscosity dependent although peaks were measured between 3.05–10.12 s−1 and 5.11–20.34 s−1 in the Dynamic Colon Model and its digital twin respectively, comparable to previous estimates of the USPII with paddle speeds of 25 and 50 rpm. It is recommended that viscosity and shear rates are considered when designing future dissolution test methodologies for colon-targeted formulations. In the USPII, paddle speeds >50 rpm may not recreate physiologically relevant shear rates. These findings demonstrate how the combination of biorelevant in vitro and in silico models can provide new insights for dissolution testing beyond established pharmacopeial methods.

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Curing of DER-331 Epoxy Resin with Arylaminocyclotriphosphazenes Based on o-, m-, and p-methylanilines

et al. 2022

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As a result of this research, it was established that the chlorine atom replacement rates in hexa-chlorocyclotriphosphazene by o-, m-, and p-methylanilines’ temperatures are crucial in determining which reaction is made. The speed of reaction practically does not affect the polarity of the synthesis solvent. For the formation of fully substituted o-, m-, and p-arilaminocyclotriphosphazenes, the reaction takes 5 h and is carried out in the diglyme at its boiling temperature. The structure of the synthesized AAP was confirmed by 31P and 1H NMR spectroscopy and MALDI-TOF mass spectrometry. By means of synchronous DSK and TGA, it is found that the synthesized AAP are crystalline and their thermal destruction has a stepped character. Thermal destruction is shown to be accompanied by the simultaneous removal of three aniline molecules from the AAP molecules. Conducted curing of epoxy resin DER-331 is carried out using the AAP as a curing agent. It has been established that due to steric difficulties, o- AAP does not interact with epoxy resin, unlike m- and p- AAP. The gel fraction in curing resin is measured, and the AAP relate to the stage processes of macromolecule formation. The result is that polymers based on DER-331 and m-, p-AAP have a gel fraction content up to 97 mass. %. These polymers have glass-transition temperatures 80 and 85 °C (m- and p-AAP-based, respectively) and demonstrate fire resistance to standard UL-94 of category V-0.

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Fluid-Structure Interaction in Coronary Stents: a Discrete Multiphysics Approach

Cited by 3 publications

References 47 publications

Finite Element Analysis of Fluid–Structure Interaction in a Model of an L-Type Mg Alloy Stent-Stenosed Coronary Artery System

Finite Element Analysis of Fluid–Structure Interaction in a Model of an L-Type Mg Alloy Stent-Stenosed Coronary Artery System

Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model

Curing of DER-331 Epoxy Resin with Arylaminocyclotriphosphazenes Based on o-, m-, and p-methylanilines

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