Fluid transport and mechanical properties of articular cartilage: A review

Mow, Van C.; Holmes, Mark H.; Lai, W. Michael

doi:10.1016/0021-9290(84)90031-9

Cited by 865 publications

(503 citation statements)

References 75 publications

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“…Therefore it is the biphasic structure of cartilage that determines its load-bearing capacity. Pressure makes fluid flow through the permeable solid phase [19][20][21][22].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

An “in vitro” experimental model to predict the mechanical behavior of macroporous scaffolds implanted in articular cartilage

Vikingsson

Ferrer

Gómez-Tejedor

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

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A model is proposed to assess mechanical behaviour of tissue engineering scaffolds and predict their performance "in vivo" during tissue regeneration. To simulate the growth of tissue inside the pores of the scaffold, the scaffold is swollen with a Poly (Vinyl alcohol) solution and subjected to repeated freezing and thawing cycles. In this way the Poly (Vinyl alcohol) becomes a gel whose stiffness increases with the number of freezing and thawing cycles. Mechanical properties of the construct immersed in water are shown to be determined, in large extent, by the water mobility constraints imposed by the gel filling the pores. This is similar to the way that water mobility determines mechanical properties of highly hydrated tissues, such as articular cartilage. As a consequence, the apparent elastic modulus of the scaffold in compression tests is much higher than those of the empty scaffold or the gel. Thus this experimental model allows assessing fatigue behaviour of the scaffolds under long-term dynamic loading in a realistic way, without recourse to animal experimentation. L. Vikingsson, et al., J Mech Behav Biomed 32 (2014) 125-131 2

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“…Therefore it is the biphasic structure of cartilage that determines its load-bearing capacity. Pressure makes fluid flow through the permeable solid phase [19][20][21][22].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

An “in vitro” experimental model to predict the mechanical behavior of macroporous scaffolds implanted in articular cartilage

Vikingsson

Ferrer

Gómez-Tejedor

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

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“…For a slow compression rate problem, defined by the inequality k H h t a 2 0 >> , the stress rise (0 < t < t o ) due to the application of a ramp displacement is given by the expression (Mow et al, 1984:…”

Section: Calculation Of Aggregate Properties From Finite Element Resultsmentioning

confidence: 99%

“…The Young's modulus (E s ), Poisson's ratio (v s ), permeability (k o ) and porosity (n) for the cartilage and degraded scaffold are given in Table 1. M = 7.8 for the cartilage tissue (Mow et al, 1984).…”

Section: Finite Element Modelmentioning

confidence: 99%

Effect of a degraded core on the mechanical behaviour of tissueengineered cartilage constructs: A poro-elastic finite element analysis

Kelly

Prendergast

2004

Med. Biol. Eng. Comput.

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The structure and functionality of tissue-engineered cartilage is determined by the tissue culture conditions and mechanical conditioning during growth. The quality of tissue-engineered cartilage may be evaluated using tests such as the confined compression test. Tissue-engineered cartilage constructs usually consist of an outer layer of cartilage and an inner core of either undeveloped cartilage or degrading scaffold material. In this paper, a biphasic poroelastic finite element model is used to demonstrate how such a core influences the reaction force vs. time curve obtained from a confined compression test. The finite element model predicts that higher volumes of degraded scaffold in the inner reduces the aggregate modulus calculated from the confined compression test and raises the estimate of tissue's permeability.The predicted aggregate modulus reduces from 0.135 MPa for a homogenous construct, to 0.068 MPa for a construct that is only 70% cartilaginous. We find that biphasic poroelastic finite modelling should be used in preference to a onedimensional model which assumes homogeniety in estimating the properties of tissueengineered cartilage.

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“…For cartilage, an internal friction is produced by the viscous drag caused when interstitial fluid flows through the porous-permeable solid matrix (Kwan, Lai et al 1984). Ploughing friction is a specific form of internal friction and occurs in diarthrodial joints when a load moves across a joint surface causing interstitial fluid flow (Linn 1967).…”

Section: Frictionmentioning

confidence: 99%

Tribology of Hemiarthroplasty

Lizhang¹

2013

Encyclopedia of Tribology

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Fluid transport and mechanical properties of articular cartilage: A review

Cited by 865 publications

References 75 publications

An “in vitro” experimental model to predict the mechanical behavior of macroporous scaffolds implanted in articular cartilage

An “in vitro” experimental model to predict the mechanical behavior of macroporous scaffolds implanted in articular cartilage

Effect of a degraded core on the mechanical behaviour of tissueengineered cartilage constructs: A poro-elastic finite element analysis

Tribology of Hemiarthroplasty

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