Fluopimomide effectively controls Meloidogyne incognita and shows a growth promotion effect in cucumber

Ji, Xiaoxue; Li, Jingjing; Meng, Zhen; Li, Na; Dong, Bing; Zhang, Shouan; Qiao, Kang

doi:10.1007/s10340-020-01247-1

Cited by 13 publications

(9 citation statements)

References 37 publications

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“…86) A nematicidal effect has also been reported for fluopimomide. 87) 5-(Trifluoromethyl)pyridine is incorporated as a substructure as well as fluopicolide, whereas the substituents on the benzene ring are characteristic. According to the FRAC classification, both compounds are reported to have the same mode of action and are classified as code 43.…”

Section: Fungicidementioning

confidence: 99%

Synthesis and application of trifluoromethylpyridines as a key structural motif in active agrochemical and pharmaceutical ingredients

et al. 2021

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Herein, we provide a brief overview of the synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives in the agrochemical and pharmaceutical industries. Currently, the major use of TFMP derivatives is in the protection of crops from pests. Fluazifopbutyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names. Several TFMP derivatives are also used in the pharmaceutical and veterinary industries; five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials. The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety. It is expected that many novel applications of TFMP will be discovered in the future.

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Section: Fungicidementioning

confidence: 99%

Synthesis and application of trifluoromethylpyridines as a key structural motif in active agrochemical and pharmaceutical ingredients

et al. 2021

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“…Moreover, many resistance proteins against R. solani infection have been identified, such as enzymes in the glycolytic pathway, chitinase and glutathione peroxidase [18]. Furthermore, fluopimomide, (N-(3-chloro-5-trifluoromethyl-pyridin-2-ylmethyl-2,3,5,6-tetrafluoro-4-methoxy-benzamide)), a new fungicide released by Shandong Sino-Agri Union Biotechnology Co. Ltd., Jinan, China [19], can effectively control diseases caused by oomycete pathogens [20], such as Meloidogyne incognita in tomato [21] and cucumber [22].…”

Section: Introductionmentioning

confidence: 99%

“…This will enhance cotton production as well as quality of cotton. [19], can effectively control diseases caused by oomycete pathogens [20], such as Meloidogyne incognita in tomato [21] and cucumber [22].…”

Section: Introductionmentioning

confidence: 99%

“…The major polysaccharides identified in Lentinan bodies had a β-(1-3)−linked D-glucopyranosyl residue as the main chain and (1-6) glucan residue on the side chain. Furthermore, fluopimomide, (N-(3-chloro-5-trifluoromethyl-pyridin-2-ylmethyl-2,3,5,6tetrafluoro-4-methoxy-benzamide)), a new fungicide released by Shandong Sino-Agri Union Biotechnology Co. Ltd., Jinan, China[19], can effectively control diseases caused by oomycete pathogens[20], such as Meloidogyne incognita in tomato[21] and cucumber[22].The use of chemical fungicides is still a major control measure against plant pathogens[21], which can negatively impact human health and the environment[23]. Alternatively, biopesticides obtained from diverse natural plants and microorganisms[24], are less hazardous to the environment as compared with chemical pesticides[25].…”

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confidence: 99%

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Use of Lentinan and Fluopimomide to Control Cotton Seedling Damping-Off Disease Caused by Rhizoctonia solani

et al. 2022

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Lentinan (LNT) is a natural and functional polysaccharide isolated from Lentinus edodes fruiting bodies, which functions in stimulating the plant immune response, improving plant disease resistance and regulating plant growth. This study explores the use of LNT as a plant growth regulator and attractant in cotton production. After treatment with LNT, the content of malondialdehyde (MDA) in cotton seeds decreased, whereas the activities of polyphenol oxidase (PPO), superoxide dismutase (SOD) and peroxidase (POD) in leaves increased significantly. LNT also promoted the growth and development of cotton plants and significantly reduced the incidence of cotton damping-off disease. The relative expression of salicylic acid pathway-related genes in cotton also increased significantly. The prevention mechanism of fluopimomide was also evaluated, and the result showed lower EC50 values and was effective in controlling cotton seedling disease caused by Rhizoctonia solani in both greenhouse experiments and field trials. The use of LNT and fluopimomide in controlling cotton seedling damping-off disease showed a synergistic effect in field trials. These results will provide a new insight into the agricultural application of LNT as a biological fungicide in the field of biological controls.

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“…It is a broad‐spectrum fungicide used to manage oomycetes including Pseudoperonospora cubensis , Phytophthora infestans and the fungal pathogen Rhizoctonia solani 2 . Most recently, it was reported that fluopimomide was inhibitory against Meloidogyne incognita 3 …”

Section: Introductionmentioning

confidence: 99%

Exposure to fluopimomide at sublethal doses causes oxidative stress in Caenorhabditis elegans regulated by insulin/insulin‐like growth factor 1‐like signaling pathway

Zhang

Liu

et al. 2022

Environmental Toxicology

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Fluopimomide is an innovative pesticide, widely used for agricultural pest management; however, little is known about its effect on non‐target organisms. This study was designed to assess the potential risk of fluopimomide and the molecular mechanisms using Caenorhabditis elegans, a common model animal. The oxidative stress‐related indicators were analyzed in C. elegans after exposure to fluopimomide for 24 h at three sublethal doses (0.2, 1.0, and 5.0 mg/L). The results demonstrated that sublethal exposure to fluopimomide adversely affected the nematodes growth, locomotive behaviors, reproduction, and lifespan, accompanying with enhanced of reactive oxygen species (ROS) generation, lipid and lipofuscin accumulation, and malondialdehyde content. In addition, exposure to fluopimomide significantly inhibited antioxidant systems including superoxide dismutase, catalase, glutathione S‐transferase, and glutathione in the nematodes. Moreover, the expression of oxidative stress‐related genes of sod‐3, hsp‐16.1, gst‐4, ctl‐2, daf‐16, and daf‐2 were significantly down‐regulated, while the expression of skn‐1 was significantly up‐regulated. Further evidence revealed that daf‐16 and skn‐1 mutant strains of C. elegans significantly decreased ROS production upon fluopimomide exposure compared with the wild‐type nematodes. Overall, our findings indicated that exposure to fluopimomide at sublethal doses caused oxidative damage, mainly associated with insulin/IGF‐1‐like signaling pathway in C. elegans. This is the first report of potential toxic effects of fluopimomide even at low concentrations, providing a new insight into the mechanisms of toxicity to C. elegans by fluopimomide.

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Fluopimomide effectively controls Meloidogyne incognita and shows a growth promotion effect in cucumber

Cited by 13 publications

References 37 publications

Synthesis and application of trifluoromethylpyridines as a key structural motif in active agrochemical and pharmaceutical ingredients

Synthesis and application of trifluoromethylpyridines as a key structural motif in active agrochemical and pharmaceutical ingredients

Use of Lentinan and Fluopimomide to Control Cotton Seedling Damping-Off Disease Caused by Rhizoctonia solani

Exposure to fluopimomide at sublethal doses causes oxidative stress in Caenorhabditis elegans regulated by insulin/insulin‐like growth factor 1‐like signaling pathway

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