Fluorescence hysteroscopy using 5‐aminolevulinic: A descriptive study

Wyss, P.; Degen, Andrea; Caduff, Rosmarie; Hornung, René; Haller, U.; Fehr, Mathias K.

doi:10.1002/lsm.10210

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…However, cases with benign disease are not truly negative controls. In particular, EH, a benign lesion, is highly positive in 5ALA-PDD [13]; therefore, it cannot be ruled out that such lesions influenced the sensitivity and specificity of the results. Moreover, we excluded patients with BMI >30 kg/m 2 .…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, 5ALA-PDD color analysis allows objective PDD assessment using a predictive formula; it increased diagnostic specificity without a marked decrease in sensitivity. Although 5ALA-PDD is used in clinical practice and studies [16−20], there are few reports of hysteroscopic 5ALA-PDD [13]. To our knowledge, this study is the first to evaluate the diagnostic sensitivity and specificity of hysteroscopic resection guided by 5ALA-PDD for AEH and EC.…”

Section: Discussionmentioning

confidence: 97%

“…A report described use of PDD for lesions in the uterine cavity [13], and 5ALA incorporation in endometrial cancer cells has been examined in vitro [14]. However, PDD has not been used for diagnosis of EC and AEH, and its diagnostic accuracy for these diseases are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

Matoba

Banno

Kisu

et al. 2020

Journal of Minimally Invasive Gynecology

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Study Objective: To examine the diagnostic accuracy of hysteroscopic photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5ALA) in patients with endometrial cancer and premalignant atypical endometrial hyperplasia. Design: A single-center, open-label, exploratory intervention study. Setting: University Hospital in Japan. Patients: Thirty-four patients who underwent hysteroscopic resection in the Department of Obstetrics and Gynecology at Keio University Hospital.Interventions: Patients were given 5ALA orally approximately 3 hours before surgery and underwent observation of the uterine cavity and endometrial biopsy using 5ALA-PDD during hysteroscopic resection. Specimens were diagnosed histopathologically and the diagnostic sensitivity and specificity of hysteroscopic 5ALA-PDD for malignancy in the uterine cavity was determined. Red (R), blue (B), and green (G) intensity values were determined from PDD images, and the relationships of histopathological diagnosis with these values were used to develop a model for objective diagnosis of uterine malignancy. Measurements and Main Results: Three patients were excluded from the study because of failure of the endoscope system. A total of 113 specimens were collected endoscopically. The sensitivity and specificity of 5ALA-PDD for diagnosis of malignancy in the uterine cavity were 93.8% and 51.9%, respectively. The R/B ratio in imaging analysis was highest in malignant lesions, followed by benign lesions and normal uterine tissue, with significant differences among these groups (p <.05). The R/B and G/B ratios were used in a formula for prediction of malignancy based on logistic regression and the area under the receiver operating characteristic curve for this formula was 0.838. At a formula cutoff value of 0.220, the sensitivity and specificity for diagnosis of malignant disease were 90.6% and 65.4%, respectively. Conclusion: To our knowledge, this is the first study of the diagnostic accuracy of 5ALA-PDD for malignancies in the uterine cavity. Hysteroscopic 5ALA-PDD had higher sensitivity and identifiability of lesions. These findings suggest that hysteroscopic 5ALA-PDD may be useful for diagnosis of minute lesions.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

Matoba

Banno

Kisu

et al. 2020

Journal of Minimally Invasive Gynecology

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“…Bronchial malignancies can be used as an example [ 55 ]. Tumors that have shown higher specificity and have the potential to be detected with 5-ALA PDD are as follows: oral and larynx cancer [ 61 , 62 ], intracranial meningioma and metastasis, prostate cancer [ 63 ], upper and urinary tract tumors [ 64 ], hepatocyte cancer, gastric cancer [ 54 , 55 ], endometrium cancer [ 65 ], ovarian cancer [ 66 ] and peritoneal carcinomatosis [ 54 ]. Different types of cancer in the same location may differ in 5-ALA-PDD visualization.…”

Section: The Mechanism Of Pddmentioning

confidence: 99%

Current Strategies in Photodynamic Therapy (PDT) and Photodynamic Diagnostics (PDD) and the Future Potential of Nanotechnology in Cancer Treatment

Olszowy,

Nowak-Perlak,

Woźniak

2023

Pharmaceutics

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Photodynamic diagnostics (PDD) and photodynamic therapy (PDT) are well-established medical technologies used for the diagnosis and treatment of malignant neoplasms. They rely on the use of photosensitizers, light and oxygen to visualize or eliminate cancer cells. This review demonstrates the recent advancements in these modalities with the use of nanotechnology, including quantum dots as innovative photosensitizers or energy donors, liposomes and micelles. Additionally, this literature review explores the combination of PDT with radiotherapy, chemotherapy, immunotherapy, and surgery for treating various neoplasms. The article also focuses on the latest achievements in PDD and PDT enhancements, which seem to be very promising in the field of oncology.

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“…Excitée par une lumière bleue autour de 400 nm, elle émet une fluorescence rouge aisément repérable et spécifique des tissus tumoraux [20]. Les premières applications cliniques du PDD en gynécologie sont récentes et utilisent l'ALA [21][22][23][24] ou un de ses dérivés méthylés, le Metvix W [25]. L'Hexvix W (dérivé ester de l'ALA) en est encore au stade de l'expérimentation animale en gynécologie [26], mais a obtenu l'AMM en urologie pour le diagnostic de cancers de la vessie [27,28].…”

Section: Photosensibilisateursunclassified

Intérêt et place de la thérapie photodynamique en gynécologie

Ascencio

Collinet

Cosson

et al. 2007

Gynécologie Obstétrique & Fertilité

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Fluorescence hysteroscopy using 5‐aminolevulinic: A descriptive study

Abstract: Fluorescence hysteroscopy following intrauterine application of ALA is feasible. Cancerous, hyperplastic, and secretory endometrial tissue showed high red fluorescence.

Cited by 12 publications

References 18 publications

Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

Current Strategies in Photodynamic Therapy (PDT) and Photodynamic Diagnostics (PDD) and the Future Potential of Nanotechnology in Cancer Treatment

Intérêt et place de la thérapie photodynamique en gynécologie

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