Fluorescence Imaging Enabled Biodegradable Photostable Polymeric Micelles

Abstract

Amphiphilic biodegradable photoluminescent polymers (ABPLPs) composed of a biodegradable fluorescent polymer and methoxy poly (ethyleneglycol) demonstrate intrinsic bright, tunable, and stable fluorescence emission. ABPLP micelles elicit minor cellular toxicity and can be used for cell and tissue imaging both in vitro and in vivo.

Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging

“…For instance, cellular internalization and intracellular trafficking of fluorescent NPs, as well as in vivo biodistribution of fluorescent NPs, can be conveniently carried out using fluorescence microscopy[21–24]. Current strategies to create fluorescent NPs include conjugating or encapsulating organic dyes or utilizing inorganic fluorescent NPs such as quantum dots (QDs) or other metallic particles[25–27].…”

“…Recently, a family of biodegradable photo-luminescent polymers (BPLPs) has been reported by Yang et al[21, 23, 32, 33]. The reactants used to synthesize BPLPs, including citric acid, amino acids, and aliphatic diols, are all compounds used in many Food and Drug Administration-regulated devices[21].…”

“…The reactants used to synthesize BPLPs, including citric acid, amino acids, and aliphatic diols, are all compounds used in many Food and Drug Administration-regulated devices[21]. In contrast to organic dyes or QDs, BPLPs have demonstrated excellent photostability and biocompatibility[21, 33]. Due to their polymeric nature, BPLPs can be conveniently used to fabricate NPs or scaffolds[21, 23].…”

“…In contrast to organic dyes or QDs, BPLPs have demonstrated excellent photostability and biocompatibility[21, 33]. Due to their polymeric nature, BPLPs can be conveniently used to fabricate NPs or scaffolds[21, 23]. …”

pH-responsive biocompatible fluorescent polymer nanoparticles based on phenylboronic acid for intracellular imaging and drug delivery

“…For example, Yang and co-workers designed a series of fluorescent amphiphilic polymers which were used as Dox vectors for simultaneous diagnosis and therapy applications. 35,36 Meanwhile, Wang and co-workers developed a gene vector based on a highly fluorescent cationic conjugated polyelectrolyte, which was used for real-time tracking of the location of gene delivery and DNA transfection. 37 Accompanied by the latest developments in nanomedicine, fluorescent polymers have huge potential in the development of tools for diagnosis and therapy.…”