Fluorescence imaging of pathophysiological microenvironments

Abstract

Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer.

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

“…, pH and polarity) are associated with cellular pathological and physiological processes. 7,90–99 Therefore, visual monitoring of changes in their indicators by NIR fluorescence imaging is essential for the diagnosis and prevention of related diseases. Intracellular pH is known to have a negative value of Log of hydrogen ion (H + ) concentration, which plays a critical role in cell growth and proliferation.…”

Synthesis and Self‐assembly of Benzoperylene Benzimidazoles: Tunable Morphology with Aggregation‐Induced Enhanced Emission

“…[14,15] We also believe that BPBIs like π-systems would be the potential candidates for supramolecular self-assembly with possible applications in the fields of optoelectronics, [1] spintronics [2] and bioimaging. [28] Experimental Section Materials, instruments, synthesis and computational studies See supporting information for details.…”

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

“…Microenvironments, including viscosity, polarity, temperature, pH, and redox balance are closely associated with many pathophysiological processes and diseases such as autophagy, inflammation, neurodegenerative disorders and even cancer. 106 Clinically, many diseases cannot be diagnosed timely until they have progressed to the middle and later stages. One of the most important obstacles to this result is that no "key-holder" can be used to indicate the progress of the disease in real time.…”