Fluorescence lifetime imaging and phasor analysis of intracellular porphyrinic photosensitizers applied with different polymeric formulations

Spadin, Florentin S.; Gergely, Lea P.; Kämpfer, Tobias; Frenz, Martin; Vermathen, Martina

doi:10.1016/j.jphotobiol.2024.112904

Journal of Photochemistry and Photobiology B: Biology

2024

DOI: 10.1016/j.jphotobiol.2024.112904

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Fluorescence lifetime imaging and phasor analysis of intracellular porphyrinic photosensitizers applied with different polymeric formulations

Florentin S. Spadin,

Lea P. Gergely,

Tobias Kämpfer

et al.

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Cited by 2 publications

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Visualisierung aktiver Zentren in elektrogesponnenen photoaktiven Membranen mittels Fluoreszenz‐Lebensdauer‐Bildgebung

Terlau,

Martin,

Galstyan

2024

Angewandte Chemie

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Interest in antibacterial nanomaterials has surged in recent years, driven by the rise in antibiotic resistance among microbes. However, their practical application remains limited because many crucial properties have yet to be thoroughly investigated. In this study, we have developed novel nanofibrous membranes based on hydrophilic polyacrylonitrile (PAN) or hydrophobic polycaprolactone (PCL) with embedded hydrophilic or hydrophobic zinc(II)phthalocyanines (ZnPcs) as photosensitizers and investigated their water disinfection properties. Several key characteristics were evaluated to link the activity of the material and composition/structure. As demonstrated by reflectance UV‐vis spectroscopy, the aggregation states of dyes within the polymer support vary significantly. We have proposed and validated the use of fluorescence lifetime imaging (FLIM) for visualizing “active sites” in the membranes. The results of this study provide useful insights for the engineering of photoactive nanomaterials with tailor‐made properties and highlight the crucial role of the nature of polymeric support in modulating the material's activity.

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Visualisierung aktiver Zentren in elektrogesponnenen photoaktiven Membranen mittels Fluoreszenz‐Lebensdauer‐Bildgebung

Terlau,

Martin,

Galstyan

2024

Angewandte Chemie

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Visualizing Active Sites in Electrospun Photoactive Membranes via Fluorescence Lifetime Imaging

Terlau,

Martin,

Galstyan

2024

Angew Chem Int Ed

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Fluorescence lifetime imaging and phasor analysis of intracellular porphyrinic photosensitizers applied with different polymeric formulations

Cited by 2 publications

References 81 publications

Visualisierung aktiver Zentren in elektrogesponnenen photoaktiven Membranen mittels Fluoreszenz‐Lebensdauer‐Bildgebung

Visualisierung aktiver Zentren in elektrogesponnenen photoaktiven Membranen mittels Fluoreszenz‐Lebensdauer‐Bildgebung

Visualizing Active Sites in Electrospun Photoactive Membranes via Fluorescence Lifetime Imaging

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