Fluorescence photography in the evaluation of acne

Lucchina, Leslie C.; Kollias, Nikiforos; Gillies, Robert J.; Phillips, Scott B.; Muccini, Joseph A.; Stiller, Matthew J.; Trancik, Ronald J.; Drake, Lynn A.

doi:10.1016/s0190-9622(96)90497-1

Cited by 87 publications

(75 citation statements)

References 22 publications

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“…Although several diagnosing techniques have been reported for determining severity level in inflammatory and noninflammatory acnes, 10,12,17 visual and touching inspections are the most frequently used techniques by dermatologists when diagnosing severity level on the affected skin zone. Huamyun and Malik 27 proved that it is possible to use multispectral and thermal images for classifying acne severity levels; their work is based on correlation computing of multispectral images.…”

Section: Discussionmentioning

confidence: 99%

“…Other techniques, having better results, suggest the use of fluorescent photography for detecting Propionibacterium acne suppression due to antibacterial agents, like benzoyl peroxide. 10,11 Several research works related to diagnosing acne severity level have been reported, most of them are based on quantifying parameters, such as types, number, distribution, and density of lesions. Although such diagnosing methods are relatively simple, dermatologists' experience and subjectivity are strongly needed.…”

Section: Introductionmentioning

confidence: 99%

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Assessment technique for acne treatments based on statistical parameters of skin thermal images

et al. 2014

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Abstract. Acne vulgaris as an inflammatory disease, with an excessive production of subdermal fat, modifies the dynamics of the bloodstream, and consequently temperature, on the affected skin zone. A high percentage of this heat interchange is manifested as electromagnetic radiation with far-infrared wavelengths, which can be captured through a thermal imaging camera. A technique based on thermal image analysis for efficiency assessment in acne vulgaris is described. The procedure is based on computing statistical parameters of thermal images captured from the affected skin zone being attended by an acne treatment. The proposed technique was used to determine the skin thermal behavior according to acne severity levels in different acne treatment stages. Infrared images of acne skin zones on eight patients, diagnosed with acne vulgaris and attended by one specific acne treatment, were weekly registered during 11 weeks. The infrared images were captured until no more improvement in affected zones was detected. The obtained results suggest a direct relationship between the used statistical parameters, particularly first-and second-order statistics, and the acne vulgaris severity level on the affected zones.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment technique for acne treatments based on statistical parameters of skin thermal images

et al. 2014

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“…Fluorescence emission has been attributed to bacterial coproporphyrin III and protoporphyrin IX [12]. The intensity of fluorescence is related to the P. acnes population.…”

Section: Methodsmentioning

confidence: 99%

A Comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin

et al. 2007

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Background and Objectives: The reaction to intense pulsed light (IPL) on Asian skin often differs from that on Caucasian skin. The study reported herein evaluated the effect on acne vulgaris of IPL alone and when IPL was combined with photodynamic therapy (PDT) using topical methyl aminolevulinate (MAL) in Asians. Study Design/Materials and Methods: Thirty Chinese subjects with phototypes IV or V and moderate acne were enrolled for a randomized, half-facial treatment study with IPL alone, IPL with PDT, or as controls. Sixteen percent MAL cream was applied to half of the face 30 minutes before treatment in the PDT group. The IPL was provided by the Ellipse Flex system (Danish Dermatologic Development, Denmark), which emitted wavelengths of 530 to 750 nm. The subjects were treated four times at 3-week intervals. Single passes of double pulses with a 10 milliseconds delay and a pulse duration of 2.5 milliseconds were used. The assessment of inflammatory and non-inflammatory acne lesions by two blinded investigators was based on standardized photographs that were taken before each treatment, and at 4 and 12 weeks after the final treatment. Results: Twenty-three patients completed the study. The mean reduction of the inflammatory lesion count was 53% in the PDT group, 22% in the IPL group, and 72% in the control group at 4 weeks, and 65% in the PDT group, 23% in the IPL group, and 88% in control group at 12 weeks. The mean clearance of non-inflammatory lesions was 52% in the PDT group, 15% in the IPL group, and 14% in the control group at 4 weeks, and 38% in the PDT group and 44% in the IPL group at 12 weeks, when and an increase of 15% was noted in the control group. Most patients experienced a reduction of inflammatory lesions that was not statistically significant on the PDT-treated side (P ¼ 0.06) or the IPLtreated side (P ¼ 0.82) at 12 weeks after treatment. Pretreatment with MAL resulted in a better clearance of inflammatory acne than IPL alone. There were no statistically significant differences between the intervention groups and the control group in the mean reduction of inflammatory lesions. Significant reductions of non-inflammatory lesions were observed in the MAL-PDT group (38%, P ¼ 0.05) and IPL groups (43%, P ¼ 0.00) 12 weeks after treatment. Twenty-five percent of the subjects in the PDT group withdrew because of intolerance to procedurerelated discomfort. Conclusions: MAL-PDT using IPL and MAL in Asians did not lead to significant improvement of moderate inflammatory acne compared with the control group. However, there was a delayed effect on non-inflammatory lesions, with significant reductions in both the PDT and IPL groups. A proportion of patients could not tolerate the discomfort that was related to PDT despite the short MAL incubation.

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“…Abnormalities in heme synthesis, occurring in cases of porphyries and some hemolytic diseases, may enhance considerably the porphyrin level within tissues [44]. Several bacteria, for example, Propionibacterium acnes, and bacteria within dental plaque (biofilm), such as Porphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens, accumulate considerable amounts of protoporphyrin [51,52]. Therefore, acne and oral and tooth lesion detection based on measurements of intrinsic fluorescence specific to porphyrin molecules appears to be a promising method of disease diagnostics.…”

Section: Fluorescence Measurementsmentioning

confidence: 99%

Sensing Glucose and Other Metabolites in Skin

Genina

Larin

Bashkatov

et al. 2012

Handbook of Biophotonics

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The sections in this article are Introduction Light–Tissue Interaction Fluorescence Measurements IR Spectroscopy Photoacoustic Technique Raman Spectroscopy Occlusion Spectroscopy Reflectance Spectroscopy Polarimetric Technique OCT Technique Conclusion Acknowledgments

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Fluorescence photography in the evaluation of acne

Cited by 87 publications

References 22 publications

Assessment technique for acne treatments based on statistical parameters of skin thermal images

Assessment technique for acne treatments based on statistical parameters of skin thermal images

A Comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin

Sensing Glucose and Other Metabolites in Skin

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