Fluorescent antibody study for antinuclear antibodies in bronchial asthma

Leopold, Howard C.; Rynes, Samuel E.; Stoloff, Irwin L.

doi:10.1016/0021-8707(65)90165-6

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Female preponderance and frequent occurrence of ANA positivity also suggest that an autoimmune mechanism may underlie non-allergic asthma. [27][28][29][30] In fact, it is well documented that autoimmune disorders have a higher prevalence in female population, and in turn ANA positivity suggests a propensity towards autoimmune phenomena. Prevalence of ANA positivity in non-allergic asthmatic patients (55% among ASSTpositive patients and 30% among ASST-negative patients) Ã Basophil histamine release: the test was considered positive when net histamine release was above 5% of total histamine content.…”

Section: Discussionmentioning

confidence: 99%

Novel clinical and serological aspects in non-allergic asthma

Comi

Tedeschi

Lorini

et al. 2007

Respiratory Medicine

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Section: Discussionmentioning

confidence: 99%

Novel clinical and serological aspects in non-allergic asthma

Comi

Tedeschi

Lorini

et al. 2007

Respiratory Medicine

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“…The disease could be triggered by one or more of the following mechanisms: hypersensitivity reactions to unidentified allergens such as fungi, recurrent or persistent infections, and autoimmune mechanisms [16,17,18,19,20]. …”

Section: Introductionmentioning

confidence: 99%

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

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Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified.

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“…Although humoral immunity to self-antigens has been described in asthmatics [7–15], the role of these Abs in the pathogenesis and progression of asthma remains unclear. However, reports from our laboratory, as well as others, have shown an immunopathogenic role of Abs to ColV in chronic rejection (BOS) following LTx [16, 17, 26].…”

Section: Discussionmentioning

confidence: 99%

“…Correlations of asthma with the prevalence of various autoimmune diseases such as Type I diabetes [5], rheumatoid arthritis [6], etc have been demonstrated. Additionally, there is evidence for a variety of auto-antibodies in patients with asthma such as anti-nuclear [7–9], anti-β 2 –adrenergic receptor [10, 11], anti-bronchial epithelial cytokeratin 18 [12], anti-alpha enolase [13, 14], and antibodies (Abs) to IgE and the high affinity IgE receptor – FcεRI [15]. However the role of these Abs in asthma still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Immune responses to self-antigens in asthma patients: clinical and immunopathological implications

et al. 2012

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Asthma leads to chronic airway inflammation that shares pathological features of chronic rejection after lung transplantation. Due to significant role of autoimmunity in chronic rejection, we hypothesized that immunity to self-antigens may also be present in asthma. The goal was to define immune responses to self-antigens in patients with asthma. Blood and clinical data were collected from 99 asthmatics and 60 controls. Serum was analyzed for antibodies (Abs) to Collagen V (ColV) by ELISA and correlated with disease severity. Asthmatics' sera were tested in human protein array to determine immune responses to other self-antigens. Asthmatics had higher concentration of Abs to ColV (predominantly IgG isotype) compared to control (p < 0.01). These Abs correlated with severe asthma (p<0.01) and corticosteroid use (p=0.032). Additionally, Abs to novel self-antigens epidermal group factor receptor (EGFr), activin A type 1 receptor, and alpha-catenin (α-catenin) were detected in asthmatics. We conclude that Abs to self-antigens (ColV, EGFr, Activin A type 1 receptor, and α-catenin) are present in asthmatics sera correlating with clinical disease. Epithelial damage from airway inflammation during asthma may result in exposure of cryptic self-antigens or their determinants resulting in immune response to self-antigens and these may contribute to pathogenesis of asthma.

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Fluorescent antibody study for antinuclear antibodies in bronchial asthma

Cited by 4 publications

References 3 publications

Novel clinical and serological aspects in non-allergic asthma

Novel clinical and serological aspects in non-allergic asthma

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Immune responses to self-antigens in asthma patients: clinical and immunopathological implications

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