Fluorescent Carbon Dioxide Indicators

Mills, Andrew; Hodgen, Stephanie

doi:10.1007/0-387-23335-0_3

Cited by 15 publications

(11 citation statements)

References 58 publications

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“…Carbon dioxide gas detection is of interest to the food, beverage, and health industries . Quantification of environmental release of carbon dioxide is also significant because of its role in global climate change.…”

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confidence: 99%

Fluorescent-Dye-Doped Sol−Gel Sensor for Highly Sensitive Carbon Dioxide Gas Detection below Atmospheric Concentrations

et al. 2009

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Optical fluorescence sol-gel sensors have been developed for the detection of carbon dioxide gas in the 0.03-30% range with a detection limit of 0.008% (or 80 ppm) and a quantitation limit of 0.02% (or 200 ppm) CO(2). Sol-gels were spin-coated on glass slides to create an organically modified silica-doped matrix with the 1-hydroxypyrene-3,6,8-trisulfonate (HPTS) fluorescent indicator. The luminescence intensity of the HPTS indicator (513 nm) is quenched by CO(2), which protonates the anionic form of HPTS. An ion pair technique was used to incorporate the lipophilic dye into the hydrophilic sol-gel matrix. TiO(2) particles (<5 microm diameter) were added to induce Mie scattering and increase the incident light interaction with the sensing film, thus increasing the signal-to-noise ratio. Moisture-proof overcoatings have been used to maintain a constant level of water inside the sensor films. The optical sensors are inexpensive to prepare and can be easily coupled to fiber optics for remote sensing capabilities. A fiber-optic bundle was used for the gas detection and shown to work as part of a multianalyte platform for simultaneous detection of multiple analytes. The studies reported here resulted in the development of sol-gel optical fluorescent sensors for CO(2) gas with sensitivity below that in the atmosphere (ca. 387 ppm). These sensors are a complementary approach to current FT-IR measurements for real-time carbon dioxide detection in environmental applications.

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confidence: 99%

Fluorescent-Dye-Doped Sol−Gel Sensor for Highly Sensitive Carbon Dioxide Gas Detection below Atmospheric Concentrations

et al. 2009

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“…In conclusion, p t CO 2 and especially p t CO 2 -p a CO 2 -gradients (regional tissue vs arterial CO 2 partial pressure) may be valuable indicators of tissue perfusion ( 100 ). Regional CO 2 -tension can be measured by tonometry or a CO 2 -sensing fluorescence dye (e.g., l-hydroxy-pyrene-3,6,8-trisulfonate (pyranine), shortly HPTS) ( 101 ) and can be performed sublingual, endogastral, transcutaneous or in the bladder ( 102 ). Technically, saline or air is enclosed by a membrane that is semi-permeable for CO 2 ( 103 ) and after equilibration of the CO 2 -partial pressure between both compartments, the content is aspired and analyzed by infrared spectrometry or conventional gas analysis methods ( 102 ).…”

Section: Technical Devices To Determine Structure and Function Of Tis...mentioning

confidence: 99%

A Toolbox to Investigate the Impact of Impaired Oxygen Delivery in Experimental Disease Models

et al. 2022

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Impaired oxygen utilization is the underlying pathophysiological process in different shock states. Clinically most important are septic and hemorrhagic shock, which comprise more than 75% of all clinical cases of shock. Both forms lead to severe dysfunction of the microcirculation and the mitochondria that can cause or further aggravate tissue damage and inflammation. However, the detailed mechanisms of acute and long-term effects of impaired oxygen utilization are still elusive. Importantly, a defective oxygen exploitation can impact multiple organs simultaneously and organ damage can be aggravated due to intense organ cross-talk or the presence of a systemic inflammatory response. Complexity is further increased through a large heterogeneity in the human population, differences in genetics, age and gender, comorbidities or disease history. To gain a deeper understanding of the principles, mechanisms, interconnections and consequences of impaired oxygen delivery and utilization, interdisciplinary preclinical as well as clinical research is required. In this review, we provide a “tool-box” that covers widely used animal disease models for septic and hemorrhagic shock and methods to determine the structure and function of the microcirculation as well as mitochondrial function. Furthermore, we suggest magnetic resonance imaging as a multimodal imaging platform to noninvasively assess the consequences of impaired oxygen delivery on organ function, cell metabolism, alterations in tissue textures or inflammation. Combining structural and functional analyses of oxygen delivery and utilization in animal models with additional data obtained by multiparametric MRI-based techniques can help to unravel mechanisms underlying immediate effects as well as long-term consequences of impaired oxygen delivery on multiple organs and may narrow the gap between experimental preclinical research and the human patient.

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“…The carbon dioxide (CO 2 ) indicator chemistry consisted of the fluorescence-based dye hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) [1] immobilized in a UV-curable silicone polymer. [2] The polymer was also spin-coated onto a microscope glass slide, and was tested in a gas flow cell against cycles of different concentrations of CO 2 .…”

Section: Carbon Dioxide Indicator Performancementioning

confidence: 99%

Battery outgassing sensor for electric drive vehicle energy storage systems

2011

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Lithium-ion batteries have been proven efficient as high power density and low self-discharge rate energy storage systems, specifically in electrical drive vehicles. An important safety factor associated with these systems is the potential hazardous release and outgassing of toxic chemical vapors such as hydrogen fluoride (HF) and hydrogen sulfides (H 2 S), and relatively elevated levels of carbon dioxide (CO 2 ). The release and accumulation of such gases emphasizes an in-line monitoring need. Intelligent Optical Systems, Inc. (IOS) has identified a viable approach for the development of an onboard optical sensor array that can be used to monitor battery outgassing. This paper discusses the potential of developing a battery outgas sensing approach that will meet sensitivity and response time requirements.

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Fluorescent Carbon Dioxide Indicators

Cited by 15 publications

References 58 publications

Fluorescent-Dye-Doped Sol−Gel Sensor for Highly Sensitive Carbon Dioxide Gas Detection below Atmospheric Concentrations

Fluorescent-Dye-Doped Sol−Gel Sensor for Highly Sensitive Carbon Dioxide Gas Detection below Atmospheric Concentrations

A Toolbox to Investigate the Impact of Impaired Oxygen Delivery in Experimental Disease Models

Battery outgassing sensor for electric drive vehicle energy storage systems

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