Fluorescent Gold Nanoclusters: Recent Advances in Sensing and Imaging

Chen, Liyi; Wang, Chia‐Wei; Yuan, Zhiqin; Chang, Huan‐Tsung

doi:10.1021/ac503636j

Cited by 757 publications

(603 citation statements)

References 148 publications

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“…It is not easy to synthesize AuNCs with DNA oligonucleotides as scaffold, possibly because the weak force between the frequently used precursor AuCl 4 -and the negatively charged DNA. However, the design and fabrication of various DNA-templated AuNCs still received broad attention since DNA template-based synthesis has several advantages.…”

Section: Dna Oligonucleotidesmentioning

confidence: 99%

“…Fluorescent AuNCs have been applied to the sensing of many inorganic anions, such as phosphate (PO 4 3-), iodide (I -), cyanide (CN -), nitrite (NO 2 -), and sulfide (S 2-). Phosphate-containing metabolites play a key role in biological systems [78].…”

Section: Detection Of Inorganic Anionsmentioning

confidence: 99%

“…Research on noble metal NCs primarily focuses on fluorescent gold nanoclusters (AuNCs) owing to their unique properties such as high fluorescence quantum yield, superior catalytic activity, low toxicity, as well as ease of preparation and bioconjugation [4,5]. Originally, AuNCs attracted significant attention as a new type of fluorophores owing to their advantageous photophysical properties, as compared to small-molecule dyes, fluorescent proteins, and quantum dots.…”

Section: Introductionmentioning

confidence: 99%

“…Over the past decade, the fluorescent AuNCs have sparked significant interest and enormous efforts have been dedicated to their development. There are already several excellent review articles dealing with AuNCs [2,4,13]; however, these reviews mainly focused on specific aspects of AuNCs. Therefore, a comprehensive and up-to-date review is of great importance to provide deep insights and inspire more exciting developments.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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Section: Dna Oligonucleotidesmentioning

confidence: 99%

Section: Detection Of Inorganic Anionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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“…Therefore, our knowledge of the geometry of metal clusters protected by organic ligands is currently improving rapidly. In addition, experimental and theoretical studies on precise metal clusters have furthered our understanding of their size-specific physical properties, including photoluminescence, 11 magnetic properties, 12 and redox behavior, [12][13][14] as well as the origins of their appearances.…”

Section: Introductionmentioning

confidence: 99%

Perspective: Exchange reactions in thiolate-protected metal clusters

et al. 2017

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Thiolate-protected metal clusters can exchange ligands or metal atoms with other substances such as coexisting ligands, complexes, and metal clusters in solution. Using these reactions, it is possible to synthesize metal clusters with new physical and chemical properties. Although the occurrence of such reactions was recognized nearly 20 years ago, their details were not well understood. In recent years, techniques for the precise synthesis of metal clusters and their characterization have progressed considerably and, as a result, details of these reactions have been clarified. In this perspective, we focus on the most-studied thiolate-protected gold clusters and provide a summary of recent findings as well as future expectations concerning the exchange reactions of these clusters.

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Nanomaterials

2018

Behaviors and Persistence of Nanomaterials in Biomedical Applications

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Fluorescent Gold Nanoclusters: Recent Advances in Sensing and Imaging

Cited by 757 publications

References 148 publications

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Perspective: Exchange reactions in thiolate-protected metal clusters

Nanomaterials

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