Fluorescent Imaging: Surface Modification of Exfoliated Layered Gadolinium Hydroxide for the Development of Multimodal Contrast Agents for MRI and Fluorescence Imaging (Adv. Funct. Mater. 21/2009)

Abstract

The synthesis of a new stable colloid of fl uorescent LGdH layers through a newly developed surface modifi cation method is reported by Y.-s. Yoon et al. This new method involves layer exfoliation, anion exchange, and PEG coating. The effi cient MRI contrastenhancement of these LGdH layers, both in vitro and in vivo, demonstrates their potential utility as a multimodal probe combining optical and MR imaging.