Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Abstract

Polyurethane (PU) is widely used in biomedical applications owing to its excellent physical and chemical properties. As an isocyanate‐free PU material, fluorescent poly(hydroxyurethane) (FPHU) is synthesized from the addition of the cyclic carbonates with amines rather than the toxic isocyanate with diols, which reduces the possible injury to the human due to trace amounts of the isocyanate residues. Herein, we report the biocompatibility of a FPHU that can be synthesized from carbon dioxide, bisepoxides, and diamine in tandem. Of unique, FPHU exhibits a strong blue fluorescence and is selectively sensitive to Fe3+ with a detection limit of 4.56 μM. The overall results of the methylthiazolyldiphenyl‐tetrazolium, cytokine release, and hemolysis assays for FPHU indicates that FPHU has much lower cytotoxicity and immunotoxicity compared with the traditional isocyanate PU, as well as a good blood compatibility with less than 5% hemolysis rate. Therefore, FPHU presents as a kind of safer PU and can be prospectively applied in medical materials.

Recent advances in the development and applications of nonconventional luminescent polymers

“…This polymer was applied for fluorometric detection of Fe 3+ , and the LOD was calculated to be 4.56 μM. 65 2.2.7. Polyesters and polycarbonates.…”

Mimicking the Mechanical Properties of Cartilage Using Ionic- and Hydrogen-Bond Cross-Linked Hydrogels with a High Equilibrium Water Content above 70%

“…These results indicated that both the pH value and osmotic pressure of the medium were not affected by hydrogel extraction. Classical cytotoxicity tests include cell viability assay, morphological observation, cell cycle detection, and apoptosis analysis, which can accurately evaluate the effects of medical materials on cell growth, reproduction, morphology, and cell damage. ,, The L929 cell line was cultured in a medium extract, three different hydrogel extracts, and 4.5% phenol medium extract for 24 h, following the requirements of national standards in GB/T 16886.12-2005/ISO 10993-12:2002. Subsequently, the Cell Counting Kit-8 (CCK-8) assay was used to assess cell viability, and cell biological morphology was observed under a microscope.…”

Polymers Based on Cyclic Carbonates as Trait d'Union Between Polymer Chemistry and Sustainable CO2 Utilization

“…[136] Strong blue fluorescence( l em = 440 nm) was detected upon irradiating the PHU with UV light (l em = 360 nm) in ethanol. PHU with M n = 11 400 gmol À1 was prepared by the reaction of HMDA with 4j.…”

“…Sebacic acid is a renewable derivative of castor oil [128] that is widelyu sed in polymers ynthesis. [136] a,a-Diglycerol is ap otentially renewable building block that can be obtained from the catalytic dimerization of glycerol. The coupling betweent he dicarboxylic acid and two equivalents of glycerol carbonate was performed by using nonrenewable N,N dimethylaminopyridine (DMAP) and N,N'-dicyclohexylcarbodiimide (DCC) as coupling reagents leading to the bis-5CC derivativeo fs ebacic acid in 85 %y ield.…”