Fluorescent probe based on N-doped carbon dots for the detection of intracellular pH and glutathione

Abstract

N-doped carbon dots used as a fluorescence probe can distinguish cancer cells from normal cells by pH and evaluate intracellular GSH.

High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid

“…1g) is mainly composed of three peaks, representing S 2p states in C–S–C, –SO 2 , and –SO 3 , respectively. 49 Fig. 1h shows the P 2p XPS spectrum, which can be divided into two peaks at 133.64 and 134.53 eV, corresponding to P–O, P–C and P–N.…”

“…1g) is mainly composed of three peaks, representing S 2p states in C-S-C, -SO 2 , and -SO 3 , respectively. 49 Fig. 1h shows the P 2p XPS spectrum, which can be divided into two peaks at 133.64 and 134.53 eV, corresponding to P-O, P-C and P-N. 50 As can be seen from Table S2, † the N,S,P-CDs were constitutive of C, H, O, N, S, and P, and the contents were, respectively, 54.66%, 7.96%, 22.89%, 6.90%, 3.06%, and 4.53%.…”

Carbon Dots for Intracellular Sensing

“…Till date, three CD-derived strategies have been established for assaying intracellular GSH. The first strategy was based on that the fluorescence of CDs can be quenched by metal ions like Fe 3þ , [202,218,219] Hg 2þ , [209,220,221] Au 3þ , [222] Ag þ , [223][224][225] and Cu 2þ , [225,226] and can be recovered upon the addition of GSH due to the higher affinity of GSH for these metal ions than that for CDs and/or the reduction of metal ions by GSH. For instance, our group synthesized CDs using glycerol and (N- [3-(trimethoxysilyl)propyl]ethylenediamine (DAMO) as the raw materials (Figure 9A).…”

Preparation and application of high-brightness red carbon quantum dots for pH and oxidized l-glutathione dual response

“…These nanoplatforms have potential applications in tumor-targeted therapy, 4 gene tracking, 5 and intracellular pH and glutathione detection. 6 Thus, it is crucial to realize the importance of the dual detection of pH and GSH in the tumor microenvironment. In addition, the abnormal levels of intracellular oxidized l -glutathione (GSSG) can lead to various diseases.…”