Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio)

Li, Meiyan; Cao, Jianhua; Zhao, Yangfei; Wu, Panhong; Li, Xuehua; Khodaei, Forouzan; Han, Yongli; Wang, Jundong

doi:10.1016/j.chemosphere.2020.127105

Cited by 42 publications

(11 citation statements)

References 52 publications

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“…Meanwhile, the previous studies have con rmed that signi cantly higher ROS and MDA levels were found in the ovaries of the uoride treated mice, suggesting that uoride has led to oxidative damage in the ovaries of zebra sh [20]. According to the previous results, we know that of SOD, CAT, and GSH-Px were decreased, and their mRNA expressions down-regulated, which may lead to reduce in antioxidant activities in uoride exposure [20], and these effects can ultimately lead to changes in cell structure and function. The antioxidant enzymes (SOD, CAT, GPx and GSH), along with malondialdehyde (MDA), were studied as potential biomarkers in oxidative damage [51].…”

Section: Discussionmentioning

confidence: 90%

“…High uoride exposure can inhibit the activity of cathepsin, trypsin and streptomycin, accompanied by promotion in the activity of transaminases (GOT and GPT); in addition, uoride can signi cantly increase the malondialdehyde (MDA) level, NO content and free OH radical production [28]. Meanwhile, the previous studies have con rmed that signi cantly higher ROS and MDA levels were found in the ovaries of the uoride treated mice, suggesting that uoride has led to oxidative damage in the ovaries of zebra sh [20]. According to the previous results, we know that of SOD, CAT, and GSH-Px were decreased, and their mRNA expressions down-regulated, which may lead to reduce in antioxidant activities in uoride exposure [20], and these effects can ultimately lead to changes in cell structure and function.…”

Section: Discussionmentioning

confidence: 97%

“…With the discovery and further understanding of mitochondrial role in apoptosis, the role of ROS in apoptosis has been paid more and more attention. Previous study showed that uoride exposure induced apoptosis has also been occurred in kidney and liver of carp, Cyprinus carpio [20]. Apoptosis and oxidation pathways are particularly important in the study of the cell-dependent molecular basis of liver and kidney damage induced by uoride [14].…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Wang

Liu

Han

et al. 2020

Preprint

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Background: Fluorine is widespread in the environment, and the injurious impacts of fluoride underscore its significance for public health. The long-term presence of fluorine in environment could be a risk in hepatotoxicity for both human beings and animals. Important role of selenium in mitigation of heavy metal toxicity via regulating autophagy and apoptosis is well-known. Further, nano-Se is a common artificial nano material, with higher biological activity and lower toxicity. The aim of the current study was to examine whether nano-Se supplementation can reduce the effects of fluoride-induced hepatocytes autophagy and apoptosis. Results: Here, we report that fluoride exposure induces apoptosis and autophagy with nucleus broken, dissolved and disappeared of hepatocyte, contributing to its hepatotoxicity. More importantly, Cyt-C and Beclin-1/Bcl-2 pathways are involved in the regulation of autophagy and apoptosis via targeting Caspase-9, Caspase-3, P53, Bax, LC3, ATG-5, P62 and mTOR expressions. Conclusion: Nano-Se is capable to alleviate fluoride-induced hepatocyte damage, that selenium can be prefer to prevent chronic fluorosis-induced autophagy and apoptosis by regulating Cyt-C and Beclin-1/Bcl-2 signaling pathway. In precisely, NaF-induced the liver injury by activating autophagy and apoptosis, which indicate that fluorine exposure, pose an ecological risk to human beings and animals. Nano-Se has protective effects against fluoride-induced hepatocytes.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Wang

Liu

Han

et al. 2020

Preprint

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“…Fluoride-induced oxidative stress in fish manifests as an increase in lipid peroxidation and consumption of GSH levels. The activity and mRNA expression levels of antioxidant enzymes, such as SOD and glutathione peroxidase (GSH-Px), significantly decreased, while the content of malondialdehyde (MDA), the end product of lipid peroxidation, significantly increased (Cao et al, 2013(Cao et al, , 2015Li et al, 2020).…”

Section: Fluorosis In a Variety Of Organisms Shows Glutathione And Glutathione Peroxidase Depletionmentioning

confidence: 99%

Prospects for the Role of Ferroptosis in Fluorosis

Zhang

Jiang

et al. 2021

Front. Physiol.

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As a strong oxidant, fluorine can induce oxidative stress resulting in cellular damage. Ferroptosis is an iron-dependent type of cell death caused by unrestricted lipid peroxidation (LPO) and subsequent plasma membrane rupture. This article indicated a relationship between fluorosis and ferroptosis. Evidence of the depletion of glutathione (GSH) and increased oxidized GSH can be found in a variety of organisms in high fluorine environments. Studies have shown that high fluoride levels can reduce the antioxidant capacity of antioxidant enzymes, while increasing the contents of reactive oxygen species (ROS) and malondialdehyde (MDA), resulting in oxidative stress and fluoride-induced oxidative stress, which are related to iron metabolism disorders. Excessive fluorine causes insufficient GSH, glutathione peroxidase (GSH-Px) inhibition, and oxidative stress, resulting in ferroptosis, which may play an important role in the occurrence and development of fluorosis.

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“…There is substantial evidence that endocrine disrupting chemicals (EDCs) can adversely affect reproductive health and may alter timing of pubertal onset (Sifakis et al 2017;Greenspan and Lee 2018;Lee et al 2019;Lucaccioni et al 2020). Moreover, animal studies show that fluoride exposure can decrease testosterone production and adversely affect testicular and ovarian development (Kinawy and Al-Eidan 2018;Orta Yilmaz et al 2018;Chaithra et al 2020;Li et al 2020). Studies conducted in China have also found associations of fluoride exposure with decreased testosterone production in men (Susheela and Jethanandani 1996;Duan et al 2016), lower estrogen levels in women (Chen et al 2015) and male infertility in regions with endemic fluorosis (Liu 1988).…”

Section: Introductionmentioning

confidence: 99%

Fluoride Exposure and Age of Menarche: Potential Differences Among Adolescent Girls and Women in the United States

et al. 2021

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Fluoride exposure is associated with later pubertal development and decreased testosterone production in adolescent and adult males. However, its effects on female reproductive health and pubertal development are unclear. Therefore, we examined associations of fluoride exposure with reproductive health outcomes among adolescent girls and women in the United States. Participants were from The National Health and Nutrition Examination Surveys (2013 to 2016), aged 16–19 and identified as female. There were 524 and 460 participants with measures of plasma fluoride and household tap water fluoride respectively, who had at least one reproductive health outcome examined, and complete covariate data. We applied covariate adjusted survey-weighted linear or logistic regression to examine associations of fluoride exposure with age of menarche, menstrual cycle regularity, or serum sex steroid hormone levels. Median interquartile range (IQR) water and plasma fluoride concentrations were 0.48 (0.53) mg/L and 0.34 (0.30) µmol/L respectively. An IQR increase in water fluoride was associated with a 3.3 month earlier first menstrual period (B = − 0.28, 95%CI − 0.54, − 0.02, p = 0.05). Additionally, we observed a significant interaction between plasma fluoride and race/ethnicity in association with age of menarche (p = 0.01). Among Non-Hispanic Black adolescents, each IQR increase in plasma fluoride was associated with a 5-month earlier age of menarche (B = − 0.42, 95%CI − 0.61, − 0.23, p < 0.001). Potential impacts of chronic low-level fluoride exposure on reproductive health outcomes are an important area of study. Current study findings, as well as potential health disparities due to disproportionate fluoride exposure should be examined in prospective studies.

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Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio)

Cited by 42 publications

References 52 publications

Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Prospects for the Role of Ferroptosis in Fluorosis

Fluoride Exposure and Age of Menarche: Potential Differences Among Adolescent Girls and Women in the United States

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