Fluoride-induced testicular degeneration and sperm quality deteriorations: Salutary role of Cyperus esculentus tubers (tiger nut) extract in animal model

Adelakun, Sunday Aderemi; Akintunde, Olalekan Wasiu; Ogunlade, Babatunde

doi:10.1016/j.androl.2020.01.003

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…The findings support the hypothesis that tiger nut maybe beneficial in the management of type 2 diabetes. In other studies, the tiger nut powder was administered to the rats daily showed anti-inflammatory and anti-apoptotic effects to prevent testicular dysfunction [ 93 ], ameliorated male arousal [ 94 ], reduced diarrheal symptoms in albino rats [ 95 ] and reduced oxidative stress in liver and inflammatory with atherosclerosis [ 96 ]. The above results are most likely related to the presence of alkaloids, quercetin, vitamins, steroids and zinc, etc., in tiger nuts.…”

Section: Medicinal Properties Of Tiger Nutmentioning

confidence: 99%

Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications

Zhang

et al. 2022

Foods

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The tiger nut is the tuber of Cyperus esculentus L., which is a high-quality wholesome crop that contains lipids, protein, starch, fiber, vitamins, minerals and bioactive factors. This article systematically reviewed the nutritional composition of tiger nuts; the processing methods for extracting oil, starch and other edible components; the physiochemical and functional characteristics; as well as their applications in food industry. Different extraction methods can affect functional and nutritional properties to a certain extent. At present, mechanical compression, alkaline methods and alkali extraction–acid precipitation are the most suitable methods for the production of its oil, starch and protein in the food industry, respectively. Based on traditional extraction methods, combination of innovative techniques aimed at yield and physiochemical characteristics is essential for the comprehensive utilization of nutrients. In addition, tiger nut has the radical scavenging ability, in vitro inhibition of lipid peroxidation, anti-inflammatory and anti-apoptotic effects and displays medical properties. It has been made to milk, snacks, beverages and gluten-free bread. Despite their ancient use for food and feed and the many years of intense research, tiger nuts and their components still deserve further exploitation on the functional properties, modifications and intensive processing to make them suitable for industrial production.

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Section: Medicinal Properties Of Tiger Nutmentioning

confidence: 99%

Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications

Zhang

et al. 2022

Foods

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“…23 Tiger nut is also considered to have a protective impact against heart disease and cancer due to its high vitamin E concentration, which aids in the development and function of red blood cells. 24 Vitamin C in tiger nut is a good antioxidant, promotes iron absorption, and helps in maintaining vitamin E levels essential for the immunological system and tissue preservation. 21 Considering the above-mentioned pharmacological properties of CES may be a good candidate for the treatment of PCOS-related metabolic and reproductive disorders.…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

Adelakun

Ojewale

Jeje

et al. 2022

Toxicology Research and Application

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Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, causes irregular menstrual cycles, dyslipidemia, excessive body weight, oxidative stress, hyperandrogenism, and infertility. This study focused on the impact of Cyperus esculentus (CES) on letrozole-induced PCOS in female Sprague-Dawley rats. Twenty (20) normal rats and twenty (20) PCOS rats (150–200 g, 8 weeks old) were randomly divided into four groups of ten ( n = 10) rats each. Group A served as normal control group received 2 mL of normal saline, group B treated with 500 mg/kg body weight of CES , group C PCOS control group received 2 mL of normal saline, and group D PCOS rats post-treated with 500 mg/kg body weight of CES daily through gastric gavage for 30 days. Estrus cyclicity, body and ovaries weights, biochemical and histological parameters were measured. Observed irregular estrus cyclicity and multiple cysts in PCOS rats, increase glycemia, ovarian weight, triglycerides, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, malondialdehyde, luteinizing hormone (LH), testosterone, and decrease high-density lipoprotein cholesterol, estradiol, progesterone, catalase, reduced glutathione (GSH), and superoxide dismutase levels, compared with control. The intervention of CES ameliorated and restored the estrus cyclicity reproductive hormone, biochemical, and structural alterations. Moreover, CES significantly decreased cystic follicles, LH, and testosterone levels, but increased estradiol concentration. This plant may be beneficial in the management and treatment of PCOS-related reproductive and metabolic disorders.

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Fluoride-Induced Sperm Damage and HuR-Mediated Excessive Apoptosis and Autophagy in Spermatocytes

Sun

Zhao

et al. 2022

Biol Trace Elem Res

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Fluoride-induced testicular degeneration and sperm quality deteriorations: Salutary role of Cyperus esculentus tubers (tiger nut) extract in animal model

Cited by 7 publications

References 35 publications

Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications

Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

Fluoride-Induced Sperm Damage and HuR-Mediated Excessive Apoptosis and Autophagy in Spermatocytes

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