Fluoride Nanoparticles for Biomedical Applications

Pudovkin, M.S.; Rakhmatullin, R. M.

doi:10.1007/978-981-13-8954-2_5

Cited by 6 publications

(1 citation statement)

References 133 publications

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“…The novelty of these materials over using 11 B in Proton-Boron Fusion Therapy (P-BFT) 9 is that when considering the use of nanocomponents in delivering the agents, there are more atoms of carbon or GdF4 in each nanoparticle targets, while in P-BFT method, there is only 1–2% wt of 11 B in each nano-target 20 , 21 which causes a very small probability of proton-boron interactions. Also, boron concentration in tumor is 100 ppm 22 , 23 but GdF4 is the agent already being used in bimodal imaging and demonstrates lower toxicity in vitro and in vivo and hence can be concentrated up to 200 ppm 24 – 26 . Moreover, 157 Gd can be used with high concentration up to 3000 ppm 27 – 30 in tumor which potentially will vanish the risk of the second cancer by the thermal neutrons.…”

Section: Introductionmentioning

confidence: 99%

Using 157Gd doped carbon and 157GdF4 nanoparticles in proton-targeted therapy for effectiveness enhancement and thermal neutron reduction: a simulation study

Tabbakh

Hosmane

Tajudin

et al. 2022

Sci Rep

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There are two major problems in proton therapy. (1) In comparison with the gamma-ray therapy, proton therapy has only ~ 10% greater biological effectiveness, and (2) the risk of the secondary neutrons in proton therapy is another unsolved problem. In this report, the increase of biological effectiveness in proton therapy has been evaluated with better performance than 11B in the presence of two proposed nanomaterials of 157GdF4 and 157Gd doped carbon with the thermal neutron reduction due to the presence of 157Gd isotope. The present study is based on the microanalysis calculations using GEANT4 Monte Carlo tool and GEANT4-DNA package for the strand breaks measurement. It was found that the proposed method will increase the effectiveness corresponding to the alpha particles by more than 100% and also, potentially will decrease the thermal neutrons fluence, significantly. Also, in this work, a discussion is presented on a significant contribution of the secondary alpha particles in total effectiveness in proton therapy.

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