Fluorinated covalent organic frameworks for efficient drug delivery

Abstract

Two novel fluorinated covalent organic frameworks as drug carriers with good biocompatibility were developed, showing excellent drug loading capacity and sustained release in vitro.

A high loading nanocarrier for the 5-fluorouracil anticancer drug based on chloromethylated graphene

“…In order to further explore the potential of the synthesized CH 2 Cl-functionalized graphene for 5-FU delivery, the obtained result was compared with some earlier studies. 57–61 As listed in Table 1, the CH 2 Cl-functionalized graphene presented an acceptable 5-FU loading percentage when compared to the other compounds, indicating its great potential as an effective carrier for 5-FU drug loading.…”

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

“…Zhai et al. [ 73 ] could synthesize two new imine‐based COF functionalized by fluorine, through the condensation‐based reaction between 2,5‐difluoro terephthalaldehyde with 4,4′,4′′‐(1,3,5‐triazine‐2,4,6‐triyl) trianiline or 1,3,5‐tri‐(4‐aminophenyl) benzene, which resulted COF‐8 and COF‐9, respectively. 5‐FU and CAP were chosen to load on the synthesized COFs as these drugs contain sulfhydryl, amide, and carboxyl groups enabling them to form Fluorine‐Hydrogen bonds with COFs.…”

Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach

“…The endocytosis of both COFs was monitored using rhodamine B dye in B16F10 cells, which showed their successful cellular uptake. 176…”

“…The endocytosis of both COFs was monitored using rhodamine B dye in B16F10 cells, which showed their successful cellular uptake. 176 Wang and co-workers reported the preparation of a delivery system for doxorubicin (DOX) and camptothecin (CPT) based on a methoxylated covalent organic framework (mCOF). Specifically, 1,3,5-tris-(4-aminophenyl)benzene (TAPB) and 2,5-dimethoxyterephthalaldehyde (DMTP) were used to form the desired mCOF with an average pore size of 2.25 nm and BET surface area of 682.3 m 2 g À1 .…”