Fluorine: Human Health Risks

Fordyce, F.M.

doi:10.1016/b978-0-444-52272-6.00697-8

Cited by 45 publications

(28 citation statements)

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“…It is also believed that hydroxyl radicals generated by H 2 O 2 might cause acute damage to cellular macromolecules in NaF-exposed cells, especially DNA, thereby leading to necrotic cell death. It is considered that fluoride uptake by water fluoridation or by treating osteoporosis does not result in severe problems which can occur by an acute and high-concentration exposure, mainly by inhalation in occupational settings (Fordyce, 2011). However, the present findings suggest that fluoride above a threshold concentration exert toxic effects sensitively on stem cells and thus the younger should pay the more caution before its treatment.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, fluoride can have double-edged sword effects on bones depending not only on the concentrations and to which bones are exposed, but also on the absorption capacity, age, and nutritional status of the individual (Caverzasio et al, 1998; Fordyce, 2011). The treatment of osteoporosis with sodium fluoride (NaF) at 20–30 mg/day exerts mostly positive effects on bone formation and water fluoridation at concentrations ranging from 1 to 2 mg/l apparently reduces dental caries prevalence (Fordyce, 2011). Otherwise, such fluoride treatments result in several disorders including enamel and skeletal fluorosis, renal toxicity, diarrhea, epithelial lung cell toxicity, and heart rate disorders (Ba et al, 2010; Everett, 2011; Fordyce, 2011; Gazzano et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The treatment of osteoporosis with sodium fluoride (NaF) at 20–30 mg/day exerts mostly positive effects on bone formation and water fluoridation at concentrations ranging from 1 to 2 mg/l apparently reduces dental caries prevalence (Fordyce, 2011). Otherwise, such fluoride treatments result in several disorders including enamel and skeletal fluorosis, renal toxicity, diarrhea, epithelial lung cell toxicity, and heart rate disorders (Ba et al, 2010; Everett, 2011; Fordyce, 2011; Gazzano et al, 2010). Fluoride is also able to induce detrimental effects on cells, although it depends on the doses and duration exposed and types of cells (Chien et al, 2006; Qu et al, 2008; Wurtz et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways

Ngoc

Son

Lim

et al. 2012

Toxicology and Applied Pharmacology

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Sodium fluoride (NaF) is used as a source of fluoride ions in diverse applications. Fluoride salt is an effective prophylactic for dental caries and is an essential element required for bone health. However, fluoride is known to cause cytotoxicity in a concentration-dependent manner. Further, no information is available on the effects of NaF on mouse embryonic stem cells (mESCs). We investigated the mode of cell death induced by NaF and the mechanisms involved. NaF treatment greater than 1 mM reduced viability and DNA synthesis in mESCs and induced cell cycle arrest in the G2/M phase. The addition of NaF induced cell death mainly by apoptosis rather than necrosis. Catalase (CAT) treatment significantly inhibited the NaF-mediated cell death and also suppressed the NaF-mediated increase in phospho-c-Jun N-terminal kinase (p-JNK) levels. Pre-treatment with SP600125 or z-VAD-fmk significantly attenuated the NaF-mediated reduction in cell viability. In contrast, intracellular free calcium chelator, but not of sodium or calcium ion channel blockers, facilitated NaF-induced toxicity in the cells. A JNK specific inhibitor (SP600125) prevented the NaF-induced increase in growth arrest and the DNA damage-inducible protein 45α. Further, NaF-mediated loss of mitochondrial membrane potential was apparently inhibited by pifithrin-α or CAT inhibitor. These findings suggest that NaF affects viability of mESCs in a concentration-dependent manner, where more than 1 mM NaF causes apoptosis through hydroxyl radical-dependent and caspase- and JNK-mediated pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways

Ngoc

Son

Lim

et al. 2012

Toxicology and Applied Pharmacology

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“…Calcium fluoride (CaF 2 ) can be found specifically related to some important areas at the Central and North of Mexico (Guanajuato, San Luis Potosí, Aguascalientes, Jalisco, Zacatecas, Chihuahua, Sonora) and is among the most stable chemical compounds. Fluoride is also found in seawater, rivers, and mineral springs, and in the stems of certain herbs, bones, and in animal teeth (Craig, Lutz, Berry & Yang, 2015;Fordyce, 2011;Tripathy, Bersillon & Gopal, 2006). The concentration of fluoride ions in water varies according to their origin.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of gamma alumina and compared with an activated charcoal on the fluoride removal from potable well water

2016

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Fluoride compounds are widely distributed in nature and are generated in many industrial processes. In many parts of the world, significant causes of diseases are associated with elevated concentrations in drinking water. In comparison with other techniques, adsorption onto a solid surface (activated alumina, activated charcoal, zeolites, etc.) is a simple, versatile, and appropriate process for removal the fluoride. In this study, we synthesized Gamma alumina (γ-Al 2 O 3 ) by homogeneous precipitation and compared its effectiveness at removing fluoride from water to a commercial brand activated charcoal. Process was carried out at pH 5 and 7. Fibrillar morphology of the γ-Al 2 O 3 powder presents high porosity in comparison with the activated charcoal that has many small pores in its compact structure. Mesoporous γ-Al 2 O 3 powder has a lower surface area (332 m 2 • g -1 ) than microporous charcoal powder (601 m 2 • g -1 ), as determined by both gas nitrogen adsorption-desorption and scanning electron microscopy. However, γ-Al 2 O 3 has a higher zeta potential and lower particle size than that determined for the activated charcoal. Adsorption isotherms of the fluoride removal concur with the Langmuir model for both adsorbents. γ-Al 2 O 3 removes up to 95.5% of fluoride ions, significantly more than the activated charcoal (26%) at pH 5. Thus, based on results obtained, the adsorption process is controlled by the diffusion of fluoride ions in liquid immediately adjacent the outer surface of the adsorbent material. RESUMENLos compuestos de fluoruro están ampliamente distribuidos en la naturaleza y se generan en varios procesos industriales. En muchas partes del mundo, las causas importantes de enfermedades están asociadas con concentraciones elevadas de estos elementos en el agua potable. En comparación con otras técnicas, la adsorción sobre una superficie sólida (alúmina activada, carbón activado, zeolitas, etc.) es un proceso simple, versátil y adecuado para la eliminación del fluoruro. La gamma alúmina (γ-Al 2 O 3 ) sintetizada por precipitación homogénea se comparó con carbón activado comercial para la eliminación del fluoruro presente en el agua. El proceso se realizó a pH 5 y pH 7. La morfología fibrilar del polvo de γ-Al 2 O 3 presenta alta porosidad en comparación con el carbón activado, que muestra una gran cantidad de pequeños poros en su estructura compacta. Según lo determinado por adsorción-desorción de gas nitrógeno, el polvo de γ-Al 2 O 3 mesoporosa tiene un área de superficie menor (332 m 2 • g -1 ) que la obtenida para el polvo de carbón activado microporoso (601 m 2 • g -1 ), concordando con la porosidad observada por microscopía electrónica de barrido. Por otra parte, la γ-Al 2 O 3 tiene un potencial zeta mayor y tamaño de partícula menor que la determinada para el carbón activado. Las isotermas de adsorción del fluoruro concuerdan con el modelo de Langmuir para ambos adsorbentes. La γ-Al 2 O 3 elimina hasta el 95.5% de ion fluoruro mucho más que el carbón activado (26%) a pH 5. Así, con...

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Aggregation‐Induced Emission, Mechanofluorochromism, and Selective Fluoride Detection by a Tripodal Salicylaldimine

Marandi¹,

Tyagi²,

Neelakandan³

2022

ChemPlusChem

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Fluoride ions are indispensable in biology and environmental science and hence the selective and sensitive detection of fluoride is important. This work reports the design and synthesis of a tripodal Schiff's base 1 through a simple condensation reaction between a commercially available aldehyde and an amine. Single crystal X‐ray crystallography revealed that compound 1 is a planar entity with the three salicylidene derivatives on the three arms of the central phenyl moiety linked by imine groups. Compound 1 forms a molecular dimer that resembles a six‐petal flower and is stabilized through multiple intermolecular interactions such as C−H.π and π.π interactions. Compound 1 exhibited moderately good emission in the solid state with aggregation induced emission and reversible mechanofluorochromic properties. Moreover, 1 was observed to selectively detect fluoride among various anions with a limit of detection of ∼9 ppm. Compound 1 was also capable of detecting fluoride under a variety of conditions such as in thin films and under cellular conditions.

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Fluorine: Human Health Risks

Cited by 45 publications

References 4 publications

Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways

Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways

Synthesis and characterization of gamma alumina and compared with an activated charcoal on the fluoride removal from potable well water

Aggregation‐Induced Emission, Mechanofluorochromism, and Selective Fluoride Detection by a Tripodal Salicylaldimine

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