Fluorocarbon associative polymers

Berret, Jean‐François; Calvet, Damien; Collet, André; Viguier, Michel

doi:10.1016/s1359-0294(03)00048-7

Cited by 125 publications

(100 citation statements)

References 74 publications

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“…Similar results have been observed with BAB (hydrophobic B blocks and hydrophilic A block) type amphiphilic copolymers which form flower-like micelles and often lead to micellar bridging (resulting in micelle aggregation) depending on environmental conditions [34][35][36][37][38]. For example, the formation of three-dimensional networks by bridging between micelles has been induced by high polymer concentration, salts and pH [34][35][36][37][38]. It is expected that as the pH of solution decreases, the PLA-b-PEG-b-polyHis micelles swell (Fig.…”

Section: Ph-dependent Structural Change Of Micellesupporting

confidence: 76%

Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine)

Lee

Kim

et al. 2007

Journal of Controlled Release

421

267

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Polymeric micelles were constructed from poly(L-lactic acid) (PLA; M n 3K)-b-poly(ethylene glycol) (PEG; M n 2K)-b-poly(L-histidine) (polyHis; M n 5K) as a tumor pH-specific anticancer drug carrier. Micelles (particle diameter: ~ 80 nm; critical micelle concentration (CMC): 2 µg/ml) formed by dialysis of the polymer solution in dimethylsulfoxide (DMSO) against pH 8.0 aqueous solution, are assumed to have a flower-like assembly of PLA and polyHis blocks in the core and PEG block as the shell. The pH-sensitivity of the micelles originates from the deformation of the micellar core due to the ionization of polyHis at a slightly acidic pH. However, the co-presence of pH-insensitive lipophilic PLA block in the core prevented disintegration of the micelles and caused swelling/ aggregation. A fluorescence probe study showed that the polarity of pyrene retained in the micelles increased as pH was decreased from 7.4 to 6.6, indicating a change to a more hydrophilic environment in the micelles. Considering that the size increased up to 580 nm at pH 6.6 from 80 nm at pH 7.4 and that the transmittance of micellar solution increased with decreasing pH, the micelles were not dissociated but rather swollen/aggregated. Interestingly, the subsequent decline of pyrene polarity below pH 6.6 suggested re-self-assembly of the block copolymers, most likely forming a PLA block core while polyHis block relocation to the surface. Consequently, these pH-dependent physical changes of the PLA-b-PEG-b-polyHis micelles provide a mechanism for triggered drug release from the micelles triggered by the small change in pH (pH 7.2-6.5).

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Section: Ph-dependent Structural Change Of Micellesupporting

confidence: 76%

Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine)

Lee

Kim

et al. 2007

Journal of Controlled Release

421

267

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“…The latter are more hydrophobic and therefore form transient networks with much longer lifetimes of the bridges [53]. They observed that if polymers containing two alkyl groups are mixed with polymers containing two fluorinated alkyl groups the relaxation of the gels is characterized by two relaxation times that reflect the escape time of either group.…”

Section: Polymers With Two Associative End-blocks (B-a-b)mentioning

confidence: 99%

Rheology of associative polymer solutions

Chassenieux

Nicolai

Benyahia

2011

Current Opinion in Colloid & Interface Science

232

202

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“…These polymers are used in industry for the production of various surface functional chemicals and possess potential applications such as water and oil repellents for textiles, surface modifiers for plastic, paper and metal, in coating, for antifogging, in cosmetics, in foams and defoaming, in graphic imaging, in greases and lubricants, etc. [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%