Fluorodeoxyglucose Uptake on Positron Emission Tomography Is a Useful Predictor of Long-Term Pain Control After Palliative Radiation Therapy in Patients With Painful Bone Metastases: Results of a Single-Institute Prospective Study

Tahara, Takatoshi; Fujii, Shinya; Ogawa, Toshihide; Michimoto, Koichi; Fukunaga, Takanobu; Tanino, Tadatoshi; Uchida, Naoshige; Matsuki, Tsutomu; Sakamoto, Hiroaki

doi:10.1016/j.ijrobp.2015.10.036

Cited by 12 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 10 studies, there were no eligibility criteria regarding systemic therapy, including chemotherapy. In 1 study, patients with a history of chemotherapy during the past 4 weeks were not eligible, 17 and 1 study's exclusion criteria included the start or change of bisphosphonate-use or systemic therapy (or both) during RT and the 10 days after completion of RT. 10 The radiation schedules frequently used were 1 Â 8 Gy, 5 Â 4 Gy, and 10 Â 3 Gy.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Pain Response Rates After Conventional Radiation Therapy for Bone Metastases in Prospective Nonrandomized Studies: A Systematic Review

Saitô

Toya

Oya

2019

Practical Radiation Oncology

View full text Add to dashboard Cite

This study aimed to determine the pain response rates after conventional radiation therapy (RT) for painful bone metastases in prospective nonrandomized studies, which better reflect daily practice than randomized controlled trials. Methods and materials: A literature search was conducted in PubMed and Scopus for articles published between 2002 and 2018. We only included articles in which pain response after RT was assessed using the International Consensus Endpoint initially published in 2002, or the updated version from 2012. In addition, to be included in this review, the study design was required to be prospective or based on prospectively collected data. Our primary outcomes of interest were the overall and complete response rates after conventional RT for bone metastases. Results: Of the 2863 articles identified in our database search, 12 met the inclusion criteria. Six studies excluded patients with features of complicated bone metastases. Only 2 papers reported exclusion criteria regarding analgesic use. Radiation schedules that were frequently used were 1 Â 8 Gy, 5 Â 4 Gy, and 10 Â 3 Gy. The overall response rate in evaluable patients was 55%, and 754 of the 1379 evaluable patients experienced a complete or partial response. The complete response rate was 15% (196 of 1348 evaluable patients). In the intent-to-treat patient group, the overall response rate was 29% (754 of 2559 enrolled patients), and the complete response rate 8% (196 of 2528 enrolled patients). Conclusions: We determined the pain response rates after conventional RT for painful bone metastases in prospective nonrandomized studies. The present review may provide benchmarks for future nonrandomized studies that investigate palliative RT for bone metastases.

show abstract

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Pain Response Rates After Conventional Radiation Therapy for Bone Metastases in Prospective Nonrandomized Studies: A Systematic Review

Saitô

Toya

Oya

2019

Practical Radiation Oncology

View full text Add to dashboard Cite

show abstract

“…Two of the 3 studies investigating changes in metabolic tumor activity assessed the relationship between metabolic tumor activity and palliative response. 22,24 Both studies found a significant relationship between changes in SUV max and pain response. Both studies measuring DW-MRI signal intensity were able to associate changes in quantitative radiologic metrics to subjective palliative outcomes.…”

Section: Resultsmentioning

confidence: 96%

“…29 Three studies in our scoping review used changes in SUV to quantitatively evaluate treatment response. 22 -24 The relationship of change in SUV to clinical palliative response differed in the 2 studies investigating this association in our review. Tahara et al found that pain responders had smaller changes in SUV max as compared to nonresponders, whereas Zhao et al found that greater changes in SUV max were associated with the improved pain response.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Diagnostic Imaging Modalities to Assess Treatment Response of Bone Metastasis in Patients Receiving Palliative Radiotherapy: A Scoping Review of the Literature

et al. 2020

View full text Add to dashboard Cite

Purpose: Several studies have used objective radiologic data to assess the effect of palliative radiotherapy on tumor burden. The purpose of this literature review was to survey the various metrics that have been used to quantify bone tumor response to palliative radiotherapy by radiographical means and to determine whether any of these metrics were associated with clinical palliative outcomes. Methods: In accordance with PRISMA extension for Scoping Reviews guidelines, a literature search Ovid Medline and OldMedline from 1946 to February 6, 2019, Embase Classic/Embase from 1947 to 2019 week 5, and Cochrane Central Register of Controlled Trials February 2019 to extract articles related to quantified radiologic evaluation of bone metastases following palliative radiotherapy. Imaging modality, quantification metric, and association between imaging modality and clinical response were recorded. Results: Fourteen articles selected for full-text review utilized computed tomography (10 studies), fluorodeoxyglucose-positron emission tomography (3 studies), magnetic resonance imaging (1 study), diffusion-weighted magnetic resonance imaging (3 studies), and X-ray (1 study) imaging modalities. Variables assessed included tumor volume regression, bone density, metabolic activity, and signal intensity. Studies differed both in the type of imaging modality used and metric derived to quantify the radiologic findings. Fifty percent of the included studies aimed to identify a relationship between a quantified radiologic metric and clinical palliative response. Of these studies, 86% reported a correlation. Conclusion: Quantified radiologic metrics can provide an objective measure of response to palliative radiotherapy and may be useful in predicting clinical palliative response. More studies are needed to validate these metrics and develop a standardized protocol for radiologic evaluation that can be implemented into a clinical workflow.

show abstract

“…18 F-FDG-PET/CT has been proven useful in assessing prognosis and monitoring treatment outcomes, and a number of studies have shown that PET parameters correlate with radiologic response in several tumor types [ 9 – 11 ]. However, few studies have reported the prediction power of 18 F-FDG-PET/CT in patients who received RT for spinal metastases [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The 18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes

et al. 2018

View full text Add to dashboard Cite

PurposeTo evaluate the potential role of 18F-fluorodeoxyglucose-positron emission tomography/computerized tomography (FDG-PET/CT) for predicting treatment response after radiotherapy (RT) in patients with spinal metastases.Materials and methodsA retrospective analysis was performed of 42 patients with spinal metastases who received RT from January 2010 to December 2014. All patients underwent FDG-PET/CT before and after treatment. Changes in metabolic responses, expressed as the maximum, mean, peak standardized uptake values (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were analyzed to determine their association with clinical outcomes.ResultsThe median age at the time of spinal metastasis diagnosis was 58 years. Median progression-free survival (PFS) and overall survival after RT were 15 months and 22.4 months, respectively. RT produced a significant decrease in SUVmean (2.27 to 1.41), SUVmax (6.87 to 2.99), SUVpeak (5.75 to 2.33) and TLG (52.84 to 24.17) when compared with the baseline values (p<0.001). The mean pain score decreased from 3.86 before RT to 0.79 after RT (p<0.001). There were significant linear relationships between maximum SUV and pain scores at baseline (r = 0.321, p = 0.038) and after treatment (r = 0.369, p = 0.016) as well as TLG at baseline (r = 0.428, p = 0.005) and after treatment (r = 0.403, p = 0.009). Local progression after treatment was identified in 12 patients (28.6%). Univariate analyses showed that >70% reduction in maximum SUV after treatment was independently associated with good PFS (p = 0.036).ConclusionsRT is an effective treatment for patients with spinal metastases, and there were significant changes in PET parameters compared with baseline. The metabolic response measured by SUV and TLG changes in FDG-PET/CT correlated with the clinical outcomes, especially with shorter PFS in patients who had higher residual maximum SUV after treatment.

show abstract

Fluorodeoxyglucose Uptake on Positron Emission Tomography Is a Useful Predictor of Long-Term Pain Control After Palliative Radiation Therapy in Patients With Painful Bone Metastases: Results of a Single-Institute Prospective Study

Cited by 12 publications

References 25 publications

Pain Response Rates After Conventional Radiation Therapy for Bone Metastases in Prospective Nonrandomized Studies: A Systematic Review

Pain Response Rates After Conventional Radiation Therapy for Bone Metastases in Prospective Nonrandomized Studies: A Systematic Review

Diagnostic Imaging Modalities to Assess Treatment Response of Bone Metastasis in Patients Receiving Palliative Radiotherapy: A Scoping Review of the Literature

The 18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes

Contact Info

Product

Resources

About