Fluorometric and colorimetric dual-mode sensing of α-glucosidase based on aggregation-induced emission enhancement of AuNCs

Li, Songrui; Zhang, Huifeng; Huang, Zhenzhen; Jia, Qiong

doi:10.1039/d3tb02532b

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02532b

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Fluorometric and colorimetric dual-mode sensing of α-glucosidase based on aggregation-induced emission enhancement of AuNCs

Songrui Li,

Huifeng Zhang,

Zhenzhen Huang

et al.

Abstract: This work firstly developed a fluorometric and colorimetric dual-mode assay platform for α-glucosidase sensing based on aggregation-induced emission enhancement of AuNCs.

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Cited by 5 publications

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A Supramolecular Gel‐Based Protocol for the Detection of α‐Glycosidases for Screening Potential Drugs

Sakthivel,

Chaturvedi,

Maitra

2024

Chemistry An Asian Journal

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α‐Glycosidases are carbohydrate‐digesting enzymes that catalyze the hydrolysis of α‑1,4‑glycopyranoside bonds from oligosaccharides and disaccharides. α‑Glucosidase is an important biomarker for the diagnosis of type‑II diabetes, Azoospermia and Pompe diseases. Additionally, mutations in α‑galactosidase lead to Fabry disease. Inhibitors targeting these enzymes are prescribed as anti‐diabetic medications and as effective chaperones for Fabry disease. Comprehending the function and regulation of α‑glycosidases requires accurate quantification methods. In this work, we highlight the design of a simple luminescent ‘turn‐on’ assay for sensing these two α‐glycosidases in a supramolecular TbCh hydrogel matrix using 1‐α‐glycosides as pro‑sensitizers. Our protocol offers a simpler and cost‐effective method for selectively sensing the detection limit of the subnanomolar range of α‐glycosidases. Importantly, the developed enzyme sensors functioned as a platform for rapid screening of drug molecules based on their inhibition potency. Therefore, the protocol is useful for facilitating the development of therapeutics and diagnostics for this important class of enzymes.

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A Supramolecular Gel‐Based Protocol for the Detection of α‐Glycosidases for Screening Potential Drugs

Sakthivel,

Chaturvedi,

Maitra

2024

Chemistry An Asian Journal

View full text Add to dashboard Cite

show abstract

Spatially confined dual-emission nanoprobes assembled from silicon nanoparticles and gold nanoclusters for ratiometric biosensing

Kong,

Li,

Yan

et al. 2024

Microchim Acta

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AIE multifunctional probe empowering colorimetric-fluorescence dual-mode biosensor for early diabetic screening

Chen,

Zhang,

Teng

et al. 2025

Biosensors and Bioelectronics

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Fluorometric and colorimetric dual-mode sensing of α-glucosidase based on aggregation-induced emission enhancement of AuNCs

Abstract: This work firstly developed a fluorometric and colorimetric dual-mode assay platform for α-glucosidase sensing based on aggregation-induced emission enhancement of AuNCs.

Cited by 5 publications

References 57 publications

A Supramolecular Gel‐Based Protocol for the Detection of α‐Glycosidases for Screening Potential Drugs

A Supramolecular Gel‐Based Protocol for the Detection of α‐Glycosidases for Screening Potential Drugs

Spatially confined dual-emission nanoprobes assembled from silicon nanoparticles and gold nanoclusters for ratiometric biosensing

AIE multifunctional probe empowering colorimetric-fluorescence dual-mode biosensor for early diabetic screening

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