Fluridil, a Rationally Designed Topical Agent for Androgenetic Alopecia: First Clinical Experience

Abstract

Topical fluridil is nonirritating, nonsensitizing, nonresorbable, devoid of systemic activity, and anagen promoting after daily use in most AGA males.

Development of fluridil, a topical suppressor of the androgen receptor in androgenetic alopecia

“…The 12-month study in male AGA volunteers also demonstrated fluridil's efficacy [Sovak et al, 2002a]. The generally observed cessation of hair loss in most patients and strengthening and regrowth of hair in some patients suggest that daily topically applied 2% fluridil is having some effect on the hair growth cycle.…”

“…Residual solvents were measured by GC headspace analysis on an HP 5890 Series II Gas Chromatograph (Hewlett Packard, Palo Alto, CA) with a 30.0 m  0.32 ID DB-1701 capillary column (J&W Scientific, Folsom, CA) by sampling (100 mL) of head space from a sealed 10-mL glass serum vial containing 250 mg of compound, 0.5 mL 1-methyl-2-pyrrolidinone, and 1-butanol internal standard at 1001C. The methods used for clinical assessment of fluridil in human patients including efficacy, safety, systemic absorption, and cumulative irritancy studies are described elsewhere [Sovak et al, 2002a] Compounds (3-amino-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl)phenyl) propanamide, (BP-34).…”

“…Serum samples were collected at 2, 5, 21, and 48 h and once every other day for 3 days thereafter. Serum samples were analyzed for the presence of fluridil and BP-34 according to the method described previously [Sovak et al, 2002a].…”

Hair: What is New in Diagnosis and Management?

“…30 In FPHL, fluridil 2% solution prevented progression of hair loss and increased hair diameter in an open clinical study. 31 Fluridil is being used throughout Europe, but is still awaiting approval from the Food and Drug Administration (FDA) in the United States.…”

Addressing Androgenetic Alopecia-A Complex Disorder-with a Multilateral Treatment Strategy

“…58 In a controlled clinical trial, once-a-day Epilobium extract treatment significantly reduced international prostate specific score in male subjects in comparison to placebo treatment over 3 months. 59 Overall, as a botanical source for a novel treatment for AGA, Epilobium species have shown significant potential and warrant further exploration owing to their potent 5α-reductase type II and PGD2 inhibiting activities.…”