Fluticasone Propionate Aerosol is More Effective for Prevention than Treatment of Recurrent Airway Obstruction

Robinson, N. E.; Berney, C.; Behan, Ashley; Derksen, F. J.

doi:10.1111/j.1939-1676.2009.0382.x

Cited by 39 publications

(73 citation statements)

References 21 publications

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“…Systemic corticosteroids may induce faster clinical benefits compared with inhaled corticosteroids during an acute exacerbation of equine asthma, as demonstrated in a study comparing the effects of aerosolised fluticasone propionate and i.v. dexamethasone on clinical findings and pulmonary function . That was a small study , and one arm was the main source of heterogeneity in this meta‐analysis, but it did provide evidence that inhaled corticosteroids have greater efficacy for prophylaxis than therapy.…”

Section: Discussionmentioning

confidence: 90%

“…dexamethasone on clinical findings and pulmonary function . That was a small study , and one arm was the main source of heterogeneity in this meta‐analysis, but it did provide evidence that inhaled corticosteroids have greater efficacy for prophylaxis than therapy. This was also confirmed in another study , which unfortunately was excluded from the current quantitative meta‐analysis because the results were expressed as median instead of mean and no error values were reported.…”

Section: Discussionmentioning

confidence: 90%

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Clinical effect of corticosteroids in asthma‐affected horses: A quantitative synthesis

Calzetta

Rogliani

Page

et al. 2018

Equine Veterinary Journal

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Inhaled corticosteroids are effective in improving the clinical condition of horses with equine asthma and prevent exacerbations. Systemic corticosteroids should be used only in selected cases with symptomatic airway hyperresponsiveness during exacerbation. IDEASS requires further validation but may represent a suitable approach to rank the level of asthma severity and assess the clinical effect of pharmacotherapy in horses with equine asthma.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Clinical effect of corticosteroids in asthma‐affected horses: A quantitative synthesis

Calzetta

Rogliani

Page

et al. 2018

Equine Veterinary Journal

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“…Furthermore, these effects are most probably elicited by the inhaled fluticasone and salbutamol used in the study. Fluticasone is a steroid that is known to dampen the release of inflammatory mediators (Robinson et al 2009) which occurs in the lungs and is associated with anoxia (Esteban et al 1999;Gitto et al 2001). Salbutamol, an inhaled bronchodilator, was reported to increase partial oxygen pressure (Robertson and Bailey 2002), reduce respiratory symptoms and improve lung function (Yuksel and Greenough 1994) in preterms with RDS.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Yıldız¹,

Ok²

2017

Vet. Med.

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Surfactant deficiency, poor development of the lung structure and fibrosis as a result of inflammation are thought to play an important role in the development of respiratory distress syndrome in premature calves. Nebulised steroid (fluticasone), bronchodilator (salbutamol) and diuretics (furosemide) can be used in combination alongside standard treatment procedures for premature calves, and might improve viability as observed in infants, foals and horses with pulmonary disorders. Twenty-five premature calves with respiratory distress syndrome were used in this study. Oxygen and supportive treatment were administered to all groups. The first group was used as a control group (Group 1). The nebulised drug combinations were as follows: Group 2: fluticasone + salbutamol, Group 3: salbutamol + furosemide, Group 4: fluticasone + furosemide and Group 5: fluticasone + salbutamol + furosemide. During the 72-h time period of the study, fluticasone (15 µg/kg/12 h), salbutamol (0.025 mg/kg/6 h) and furosemide (1 mg/kg/12h) were applied for 5 min. Arterial blood samples were collected from the auricular artery at 0 h and at 1, 24, 48 and 72 h for blood gas analysis. Significant (P < 0.05) increases in arterial partial oxygen, oxygen saturation and peripheral oxygen saturation and decreases in arterial partial carbon dioxide, lactate and respiration rate were observed in all the nebulised treatment groups, while a statistical difference was observed only for arterial partial carbon dioxide in control group. When comparing the treated groups with the control, it may be concluded that nebulised drugs are highly effective in the therapy of premature calves with respiratory distress syndrome, while the different nebulised groups exhibited similar efficacies.

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“…dexamethasone (0.1 mg/kg bwt q. 24 h) in RAO horses . In comparison, the administration of both preparations prevented the development of airway obstruction when used prophylactically .…”

Section: Drug Therapymentioning

confidence: 99%

Recurrent airway obstruction: A review

Pirie

2014

Equine Veterinary Journal

108

115

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Recurrent airway obstruction is a widely recognised airway disorder, characterised by hypersensitivity-mediated neutrophilic airway inflammation and lower airway obstruction in a subpopulation of horses when exposed to suboptimal environments high in airborne organic dust. Over the past decade, numerous studies have further advanced our understanding of different aspects of the disease. These include clarification of the important inhaled airborne agents responsible for disease induction, improving our understanding of the underlying genetic basis of disease susceptibility and unveiling the fundamental immunological mechanisms leading to establishment of the classic disease phenotype. This review, as well as giving a clinical overview of recurrent airway obstruction, summarises much of the work in these areas that have culminated in a more thorough understanding of this debilitating disease.

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Fluticasone Propionate Aerosol is More Effective for Prevention than Treatment of Recurrent Airway Obstruction

Abstract: FP (6 mg q12h) is as effective as DEX for prevention of acute exacerbations of RAO and lower doses should be evaluated. High-dose FP is not as effective as DEX for treatment of RAO exacerbations.

Cited by 39 publications

References 21 publications

Clinical effect of corticosteroids in asthma‐affected horses: A quantitative synthesis

Clinical effect of corticosteroids in asthma‐affected horses: A quantitative synthesis

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Recurrent airway obstruction: A review

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