Fluticasone versus placebo for chronic asthma in adults and children

Adams, Nick; Bestall, Janine C; Lasserson, Toby J; Jones, Paul; Cates, Christopher J

doi:10.1002/14651858.cd003135.pub4

Cited by 76 publications

(38 citation statements)

References 110 publications

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“…9 One of the most common local adverse effects of ICS therapy is dysphonia, with an incidence that reportedly varies from 5% to 58%. In 1974, Williams et al 10 described an incidence of transient dysphonia in 55% of patients who received treatment using triamcinolone acetonide aerosol.…”

Section: Incidence Of Dysphoniamentioning

confidence: 99%

Practical Considerations for Dysphonia Caused by Inhaled Corticosteroids

Galván

Guarderas

2012

Mayo Clinic Proceedings

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Inhaled corticosteroid (ICS) therapy has become standard in the treatment of asthma. A common local adverse effect of ICS therapy is dysphonia, which has been reported to affect 5% to 58% of patients. Although causes of dysphonia associated with ICS therapy have been underinvestigated, it may result from deposition of an active ICS in the oropharynx during administration, which then causes myopathy or a mucosal effect in the laryngopharynx. Use of ICS should be considered during any evaluation of dysphonia. We recommend using the lowest effective dosage of ICS, administering medication with a spacer, gargling, rinsing the mouth and washing the face after inhalation, and washing the spacer. If dysphonia develops despite these interventions, ICS use should be suspended until symptoms resolve, provided that asthma control is not compromised.

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Section: Incidence Of Dysphoniamentioning

confidence: 99%

Practical Considerations for Dysphonia Caused by Inhaled Corticosteroids

Galván

Guarderas

2012

Mayo Clinic Proceedings

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“…Regular treatment with ICS reduces inflammation, swelling and mucus production in the lungs, resulting in better airflow in and out of the airways, fewer exacerbations, better control of symptoms and lung function and ultimately a reduction in hospital admissions and deaths from asthma. [55][56][57] The anti-inflammatory effects may take from 1 to 3 weeks to become apparent 58 and it may take up to 12 weeks of regular daily treatment before maximum benefit is seen. However, the length of time taken to achieve maximal treatment benefit is dependent on both asthma severity at baseline and the outcome measure used to assess treatment effect.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

Shepherd¹,

Rogers²,

Anderson³

et al. 2008

Health Technol Assess

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“…Beclomethasone dipropionate is available in a range of formulations as metered dose inhalers and various dry powder inhaler devices (Adams et al, 2009). It is also worth mention that fluticasone propionate and beclomethasone dipropionate are two commonly inhaled glucocorticoids for the treatment of asthma (Ahmadiafshar et al, 2010).…”

Section: Glucocorticoidsmentioning

confidence: 99%