Flux modeling for monolignol biosynthesis

Wang, Jack; Matthews, Megan L.; Naik, Punith P.; Williams, Cranos M.; Ducoste, Joel J.; Sederoff, Ronald R.; Chiang, Vincent L.

doi:10.1016/j.copbio.2018.12.003

Cited by 47 publications

(28 citation statements)

References 52 publications

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“…Metabolic flux redirection within the lignin biosynthesis pathway is considered to be a determinant of lignin property and benefits the lignin engineering for improved plant development and utilization (Wang et al, 2019a). For example, overexpression of F5H in COMT downregulated lines leads to increased levels of 5‐OH units and reduced levels of G unit lignin.…”

Section: Metabolic Flux Redirectionmentioning

confidence: 99%

Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions

Dong

Lin

2021

JIPB

828

429

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Phenylpropanoid metabolism is one of the most important metabolisms in plants, yielding more than 8,000 metabolites contributing to plant development and plant-environment interplay. Phenylpropanoid metabolism materialized during the evolution of early freshwater algae that were initiating terrestrialization and land plants have evolved multiple branches of this pathway, which give rise to metabolites including lignin, flavonoids, lignans, phenylpropanoid esters, hydroxycinnamic acid amides, and sporopollenin. Recent studies have revealed that many factors participate in the regulation of phenylpropanoid metabolism, and modulate phenylpropanoid homeostasis when plants undergo successive developmental processes and are subjected to stressful environments. In this review, we summarize recent progress on elucidating the contribution of phenylpropanoid metabolism to the coordination of plant development and plantenvironment interaction, and metabolic flux redirection among diverse metabolic routes. In addition, our review focuses on the regulation of phenylpropanoid metabolism at the transcriptional, post-transcriptional, post-translational, and epigenetic levels, and in response to phytohormones and biotic and abiotic stresses.

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Section: Metabolic Flux Redirectionmentioning

confidence: 99%

Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions

Dong

Lin

2021

JIPB

828

429

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“…The monolignols are then transported to the lignifying zone and oxidized by peroxidases and laccases to phenoxy radicals for polymerization (Li et al ., 2014; Sulis and Wang, 2020). The 11 enzyme families involved in monolignol biosynthesis are phenylalanine ammonia‐lyase (PAL), cinnamate‐4‐hydroxylase (C4H), 4‐coumarate:CoA ligase (4CL), p ‐hydroxycinnamoyl‐CoA: shikimate p ‐hydroxycinnamoyltransferase (HCT), p ‐coumarate 3‐hydroxylase (C3H), caffeoyl shikimate esterase (CSE), caffeoyl‐CoA O‐methyltransferase (CCoAOMT), cinnamoyl‐CoA reductase (CCR), coniferaldehyde 5‐hydroxylase (CAld5H), 5‐hydroxyconiferaldehyde O ‐methyltransferase (AldOMT), and cinnamyl alcohol dehydrogenase (CAD) (Li et al ., 2014; Wang et al ., 2019b).…”

Section: Plant Biomass Feedstocks With Industrial Potentialmentioning

confidence: 99%

Thermophilic microbial deconstruction and conversion of natural and transgenic lignocellulose

Bing

Sulis

Wang

et al. 2021

Environ Microbiol Rep

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The potential to convert renewable plant biomasses into fuels and chemicals by microbial processes presents an attractive, less environmentally intense alternative to conventional routes based on fossil fuels. This would best be done with microbes that natively deconstruct lignocellulose and concomitantly form industrially relevant products, but these two physiological and metabolic features are rarely and simultaneously observed in nature. Genetic modification of both plant feedstocks and microbes can be used to increase lignocellulose deconstruction capability and generate industrially relevant products. Separate efforts on plants and microbes are ongoing, but these studies lack a focus on optimal, complementary combinations of these disparate biological systems to obtain a convergent technology. Improving genetic tools for plants have given rise to the generation of low-lignin lines that are more readily solubilized by microorganisms. Most focus on the microbiological front has involved thermophilic bacteria from the genera Caldicellulosiruptor and Clostridium, given their capacity to degrade lignocellulose and to form bio-products through metabolic engineering strategies enabled by ever-improving molecular genetics tools. Bioengineering plant properties to better fit the deconstruction capabilities of candidate consolidated bioprocessing microorganisms has potential to achieve the efficient lignocellulose deconstruction needed for industrial relevance.

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“…Owing to the recalcitrant chemical nature and the complexity of lignin, lignin limits the conversion efficiency of lignocellulosic biomass to ethanol (Poovaiah et al, 2014;Vanholme et al, 2010). Modifying trees to have less lignin or more-degradable lignin along with normal growth, can reduce the high processing costs Full-size DOI: 10.7717/peerj.10741/fig- 1 and carbon footprint of making paper, biofuels, and chemicals (Ralph, Lapierre & Boerjan, 2019;Tang & Tang, 2014;Wang et al, 2019;Xu & Li, 2016;Zhao, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The biosynthetic pathway for lignin has been studied extensively and the phenylpropane pathway which begins with phenylalanine, is responsible for monolignol biosynthesis. (Boerjan, Ralph & Baucher, 2003;Karkonen & Koutaniemi, 2010;Maeda, 2016;Ralph, Lapierre & Boerjan, 2019;Vanholme et al, 2010;Wang et al, 2019;Xu & Li, 2016). Monolignol is the general name for lignin building blocks.…”

Section: Introductionmentioning

confidence: 99%

Characterization and functional analysis of the Hydroxycinnamoyl-CoA: shikimate hydroxycinnamoyl transferase (HCT) gene family in poplar

Chen

et al. 2021

PeerJ

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Hydroxycinnamoyl-CoA: shikimate hydroxycinnamoyl transferase (HCT) divides the mass flux to H, G and S units in monolignol biosynthesis and affects lignin content. Ten HCT homologs were identified in the Populus trichocarpa (Torr. & Gray) genome. Both genome duplication and tandem duplication resulted in the expansion of HCT orthologs in Populus. Comprehensive analysis including motif analysis, phylogenetic analysis, expression profiles and co-expression analysis revealed the divergence and putative function of these candidate PoptrHCTs. PoptrHCT1 and 2 were identified as likely involved in lignin biosynthesis. PoptrHCT9 and 10- are likely to be involved in plant development and the response to cold stress. Similar functional divergence was also identified in Populus tomentosa Carr. Enzymatic assay of PtoHCT1 showed that PtoHCT1 was able to synthesize caffeoyl shikimate using caffeoyl-CoA and shikimic acid as substrates.

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Flux modeling for monolignol biosynthesis

Cited by 47 publications

References 52 publications

Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions

Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions

Thermophilic microbial deconstruction and conversion of natural and transgenic lignocellulose

Characterization and functional analysis of the Hydroxycinnamoyl-CoA: shikimate hydroxycinnamoyl transferase (HCT) gene family in poplar

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