Focal Epithelial Hyperplasia: Heck Disease

Cohen, Philip R.; Hebert, Adelaide A.; Adler‐Storthz, Karen

doi:10.1111/j.1525-1470.1993.tb00369.x

Cited by 37 publications

(27 citation statements)

References 42 publications

(69 reference statements)

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“…Described formally in 1965 in Native-Americans by Heck [1], this pathology is frequent in populations of 2-13 years of age, and its incidence is unequally distributed worldwide, affecting Native-Americans and indigenous populations the most [1][2][3][4][5][6]. There is no concrete evidence of affection of a particular male or female gender, as this varies with previous studies [7].…”

Section: Introductioncontrasting

confidence: 53%

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

Zavala-Garcia¹,

Briceño-Mena²,

Romero-Beltran³

et al. 2017

J immuno Biol

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Heck's disease, or Focal Epithelial Hyperplasia (FEH), caused by Human Papilloma Virus (HPV) subtypes 13 and mainly 32, is a rare and benign pathology of the oral mucosa; diagnosis is confirmed by PCR analysis. This is a common disease in the Mayan and other Native-American populations, most frequently between 2-13 years. Risk factors include lower income class, poor hygiene and genetic predisposition.This cross-sectional study aims to determine the prevalence of clinically compatible lesions of FEH in children from low, middle and high-income in 3 elementary schools in Yucatan, Mexico.Clinical evaluation was conducted and documented for later analysis by a dermatologist familiar with FEH. Samples were taken and HPV-13 was identified by PCR.The total of 186 subjects were analyzed from the low-income elementary school, with 41 subjects presenting FEH lesions and 76 presented HPV-13 upon PCR analysis. In the middle-income school, of the 144 subjects studied, 3 had FEH lesions and 8 presented HPV-13 upon PCR analysis. In the high-income elementary school, 96 students were studied, and none presented FEH lesions, however, 6 had HPV-13 positivity.FEH and HPV-13 prevalence were inversely proportional to socioeconomic status. Lacking an association to a particular gender or difference in the age groups studied.

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Section: Introductioncontrasting

confidence: 53%

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

Zavala-Garcia¹,

Briceño-Mena²,

Romero-Beltran³

et al. 2017

J immuno Biol

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show abstract

“…9,32 The childhood preponderance may also be due to investigator bias, however, as many of the investigations have only reviewed school age groups. 26 A genetic predilection for FEH has been proposed, 1,22 as it is largely confined to certain geographic regions and to certain ethnic populations within these locations; however, few familial cases have been reported to support this contention, 2,25,33,34 and no HLA studies have been undertaken to confirm this proposal.…”

Section: Epidemiologymentioning

confidence: 99%

Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature.

Marvan¹,

Firth

1998

Australian Dental Journal

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Focal epithelial hyperplasia (FEH) is a rare but distinctive entity of viral aetiology with characteristic clinical and histopathological features. It is usually seen in children and adolescents of American Indian and Eskimo background; however, it has recently been described in adults who are HIV positive. Suppression of the immune system leaves the individual vulnerable to opportunistic infections. With improved management of immunocompromised patients it is increasingly possible that the general dental practitioner will encounter secondary oral infections such as FEH and must therefore be able to recognize, diagnose and treat these lesions. The following report presents a case of FEH in an HIV-infected man, and is followed by a review of the literature.

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“…Nas crianças, é muito importante fazer o diagnóstico diferencial da HEF do Condiloma Acuminado (CA), que é uma doença sexualmente transmissível e indica que o paciente infantil pode estar sofrendo de abuso sexual (COHEN; HEBER; ADLER-STORTHZ;1993;GUILL et al, 2002). Embora o CA seja clinicamente muito parecido com a HEF, esta patologia geralmente esta associada ao HPV 6 e 11 (EVERSOLE et al, 1987;HENLEY;SUMMERLIN;TOMICH, 2004).…”

Section: Resultsunclassified

Hiperplasia Epitelial Focal: Uma Revisão De Literatura Narrativa

Rosa

Azevedo

Cutrim

et al. 2017

RCCP

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RESUMO:O objetivo deste estudo foi descrever a doença Hiperplasia Epitelial Focal (HEF), caracterizando sua aparência e o seu diagnóstico, a partir de uma revisão de literatura. A HEF afeta mais as meninas. Clinicamente, essa doença apresenta-se como nódulos e/ou pápulas múltiplas de coloração igual da mucosa normal localizados lábios, mucosa jugal e língua. Esta doença está diretamente relacionada com a infecção pelo Papiloma Vírus Humano sendo relacionada no contexto do abuso sexual infantil. E por fim, para que o diagnóstico da HEF possa ser feito, o cirurgião dentista deve estar atento ao exame clínico e aos dados sócio-demográficos do paciente, junto com exames histológicos e o tipo de HPV. Portanto, é importante conhecer tal patologia. PALAVRAS-CHAVE: Hiperplasia epitelial focal. Doença de Heck. Papiloma vírus Humano (HPV).ABSTRACT: Objective of this study was to describe the Focal Epithelial Hyperplasia (HEF) disease, characterizing its appearance and its diagnosis, based on a review of narrative literature. HEF affects girls more. Clinically this disease presents as nodules and / or multiple papules of equal coloration of the normal mucosa located lips, jugal mucosa and tongue. This disease is directly related to Human Papilloma Virus infection being related in the context of child sexual abuse. Finally, in order for the HEF diagnosis to be made, the dental surgeon must be attentive to the clinical examination and the patient's socio-demographic data, together with histological exams and the type of HPV. Therefore, it is important to know this pathology.

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Focal Epithelial Hyperplasia: Heck Disease

Cited by 37 publications

References 42 publications

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature.

Hiperplasia Epitelial Focal: Uma Revisão De Literatura Narrativa

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