Focal nodular liver hyperplasia as a late complication that occurs after autologous hematopoietic stem cell transplantation in children with neuroblastoma (clinical case and literature review)

Abstract

Focal nodular hyperplasia (FNH) is a regenerative volumetric liver formation that can occur as a result of the reaction of hepatocytes to local vascular circulatory disorders and is one of the late complications in patients who received high-dose chemotherapy followed by hematopoietic stem cell transplantation. This article presents a description of two clinical cases of development of liver FNH in patients with high-risk neuroblastoma identified in the late stages from the end of specific treatment. A possible reason for the development of liver FNH in these patients could be the use of alkylating drugs (ifosfamide, threosulfan, busulfan, melphalan).