Focus on ferroptosis regulation: Exploring novel mechanisms and applications of ferroptosis regulator

Ma, Teng; Chen, Jing-Xian; Zhu, Peng; Zhang, Chao-Bin; Zhou, Yong; Duan, Jia‐Xi

doi:10.1016/j.lfs.2022.120868

Cited by 42 publications

(21 citation statements)

References 156 publications

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“…Therefore, the specific targeting of ferroptosis regulators to particular cells and the precise delivery to certain organs must be guaranteed, which requires further pharmaceutical investigations. Additionally, emergent evidence has shown that ferroptosis can be considered with iron-dependent regulatory necrosis, tightly associated with several cell death pathways, including autophagy, pyroptosis, necrosis, and apoptosis ( Yee et al, 2020 ; Ma et al, 2022 ), but the exact molecular interaction has not been fully elucidated at present. Therefore, it is critical to unravel their interplays to facilitate the designing of novel therapeutic measures with the integrated regulation of several cell death pathways.…”

Section: Discussionmentioning

confidence: 99%

Regulatory mechanism and research progress of ferroptosis in obstetrical and gynecological diseases

Wang

Wei

et al. 2023

Front. Cell Dev. Biol.

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Ferroptosis is a novel type of regulated cell death driven by iron-dependent lipid peroxidation, which is distinguished from traditional types of programmed cell death, such as apoptosis, proptosis and necrosis et al. Impaired iron homeostasis, lipid peroxidation and antioxidants depletion are three hallmarks of ferroptosis. Over the past years, emerging studies support the notion that ferroptosis might be involved in the pathology of obstetrical and gynecological diseases, including preeclampsia (PE), endometriosis (EMs) and polycystic ovarian syndrome (PCOS). In the PE condition, the high sensitivity of trophoblasts towards ferroptosis has been found to potentially link to inflammation, suboptimal vascular remodeling and aberrant hemodynamics, which are three prominent pathophysiological features of PE. As for EMs, compromised ferroptosis of endometrial cells was associated with the formation ectopic lesions, whereas in the nearby lesions, the presence of ferroptosis was suggested to promote the progression of EMs, contributing to the relative clinical manifestations. Ferroptosis has been implicated a crucial role in the initiation of ovarian follicular atresia, which might help to manage ovulation in PCOS patients. Taken together, this review explored the basis of ferroptosis mechanisms and comprehensively summarized the latest discovery of roles of ferroptosis on PE, EMs and PCOS, gaining a deeper insight into the pathogenesis of these obstetrical and gynecological diseases and investigation of novel therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Regulatory mechanism and research progress of ferroptosis in obstetrical and gynecological diseases

Wang

Wei

et al. 2023

Front. Cell Dev. Biol.

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“…Many studies have shown the importance of maintaining an adequate function of the GPX4. Knockout of GPX4 is embryonically lethal [17]. Besides, Yoo et al demonstrated that adults whose GPX4 were knocked out showed lower drug resistance in a mouse model [18].…”

Section: Important Regulatory Targets In Ferroptosis Metabolic Pathwaymentioning

confidence: 99%

Recent progress in ferroptosis: inducers and inhibitors

Guo

2022

Cell Death Discov.

125

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Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities in pursuit to reveal the mechanism and key targets of ferroptosis because ferroptosis is closely related to the pathophysiological processes of many diseases. Recent studies have shown some key targets, such as glutathione peroxidase 4 (GPX4) and System Xc−, and several inducers and inhibitors have been developed to regulate these key targets. With the emergence of new ferroptosis targets, studies on inducers and inhibitors have made new developments. The selection and use of inducers and inhibitors are very important for related work. This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and inhibitors, and discusses their medical application. The paper ends of with potential future research direction for ferroptosis.

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“…Ferroptosis is an iron‐dependent death pattern characterized by the accumulation of lipid peroxides. [ 34 ] It may mainly be achieved by increasing iron load, inhibiting GPX4 activity and regulating lipid metabolism.…”

Section: Non‐apoptotic Modementioning

confidence: 99%

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Meng

Ding

et al. 2023

Small Methods

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Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) and immunogenic cell death (ICD), as important cell death mechanisms, are widely reported in cancer therapy, and understanding the relationship between the two is significant for clinical tumor treatments. Considering that vast nanodrugs are developed to induce tumor PCD and ICD simultaneously, in this review, the interrelationship between PCD and ICD is described using nanomedicines as examples. First, an overview of PCD patterns and focus on the morphological differences and interconnections among them are provided. Then the interrelationship between apoptosis and ICD in terms of endoplasmic reticulum stress is described by introducing various cancer treatments and the recent developments of nanomedicines with inducible immunogenicity. Next, the crosstalk between non‐apoptotic (including necrosis, ferroptosis, pyroptosis, and autophagy) signaling pathways and ICD is introduced and their relationship through various nanomedicines as examples is further illustrated. Finally, the relationship between PCD and ICD and its application prospects in the development of new ICD nanomaterials are summarized. This review is believed to deepen the understanding of the relationship between PCD and ICD, extend the biomedical applications of various nanodrugs, and promote the progress of clinical tumor therapy.

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Focus on ferroptosis regulation: Exploring novel mechanisms and applications of ferroptosis regulator

Cited by 42 publications

References 156 publications

Regulatory mechanism and research progress of ferroptosis in obstetrical and gynecological diseases

Regulatory mechanism and research progress of ferroptosis in obstetrical and gynecological diseases

Recent progress in ferroptosis: inducers and inhibitors

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

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