“…However, the molecular mechanism by which posttranscriptional splicing occurs, particularly in its spatial context, is not fully understood (Vargas et al, 2011). Importantly, splicing is not only the process coupled with transcription; indeed, capping, RNA editing, and 3 0 end processing occur in a cotranscriptional manner (Bentley, 2014;Martinez-Rucobo et al, 2015;Millevoi & Vagner, 2009;Proudfoot, Furger, & Dye, 2002;Rodriguez, Menet, & Rosbash, 2012), suggesting that cells have mechanisms to select and turn on individual processing machinery at appropriate times. Several mechanisms have been reported to maintain the accuracy of RNA processing.…”