Focus: Schistosomiasis

Chitsulo, Lester; LoVerde, Philip T.; Engels, Dirk

doi:10.1038/nrmicro801

Cited by 243 publications

(227 citation statements)

References 21 publications

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“…where 25 million people are infected with the human immunodeficiency virus (HIV) and an estimated 170 million people are infected with chronic schistosomiasis. 6 As a result, the prevalence of co-infected individuals has been shown to reach high proportions. 7 Even though an HIV vaccine will be broadly applied for preventing HIV infection, the impact of HIV vaccination on the progression of schistosomiasis in co-infected persons has been questioned.…”

Section: Introductionmentioning

confidence: 99%

IL-4 and IFN-γ induced by human immunodeficiency virus vaccine in a schistosome infection model

Yin

Dai

Arango

et al. 2012

Human Vaccines & Immunotherapeutics

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Section: Introductionmentioning

confidence: 99%

IL-4 and IFN-γ induced by human immunodeficiency virus vaccine in a schistosome infection model

Yin

Dai

Arango

et al. 2012

Human Vaccines & Immunotherapeutics

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“…Many of the more than 18,000 species of digenetic trematodes (digeneans) found worldwide have a significant impact on animal and human health (16). Among them, schistosomes afflict more than 200 million persons, mostly in sub-Saharan Africa (17). Almost all digenean species depend on molluscs, usually snails, for their larval development, a relationship characterized by a high degree of specificity (18).…”

mentioning

confidence: 99%

Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection

Hanington

Forys

Dragoo

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

132

139

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Invertebrates lack adaptive immune systems homologous to those of vertebrates, yet it is becoming increasingly clear that they can produce diversified antigen recognition molecules. We have previously noted that the snail Biomphalaria glabrata produces a secreted lectin, fibrinogen-related protein 3 (FREP3), unusual among invertebrate defense molecules because it is somatically diversified by gene conversion and point mutation. Here we implicate FREP3 in playing a central role in resistance to a major group of snail pathogens, digenetic trematodes. FREP3 is up-regulated in three models of resistance of B. glabrata to infection with Schistosoma mansoni or Echinostoma paraensei, and functions as an opsonin favoring phagocytosis by hemocytes. Knock-down of FREP3 in resistant snails using siRNA-mediated interference resulted in increased susceptibility to E. paraensei, providing a direct link between a gastropod immune molecule and resistance to trematodes. FREP3 up-regulation is also associated with heightened responsiveness following priming with attenuated digenetic trematodes (acquired resistance) in this model invertebrate immune system. host-parasite interactions | evolution | immunology | parasitology | schistosomiasis

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“…Schistosomiasis is a chronic disease endemic in 76 countries worldwide, causing an estimated 200 000 deaths/year [1]. Mass chemotherapy is the control strategy used nowadays; however, this control strategy has some drawbacks, such as a high frequency of reinfection and the difficulties and costs involving the long-lasting maintenance of these programmes [2].…”

Section: Introductionmentioning

confidence: 99%

Identification of paramyosin T cell epitopes associated with human resistance toSchistosoma mansonireinfection

Fonseca

Cunha-Neto

Goldberg

et al. 2005

Clinical and Experimental Immunology

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SummaryParamyosin, a Schistosoma mansoni myoprotein associated with human resistance to infection and reinfection, is a candidate antigen to compose a subunit vaccine against schistosomiasis. In this study, 11 paramyosin peptides selected by TEPITOPE algorithm as promiscuous epitopes were produced synthetically and tested in proliferation and in vitro human leucocyte antigen (HLA)-DR binding assays. A differential proliferative response was observed in individuals resistant to reinfection compared to individuals susceptible to reinfection in response to Para (210-226) peptide stimulation. In addition, this peptide was able to bind to all HLA-DR molecules tested in HLA-DR binding assays, confirming its promiscuity. Para (6-22) and Para (355-371) were also shown to be promiscuous peptides, because they were able to bind to the six and eight most prevalent HLA-DR alleles used in HLA-DR binding assays, respectively, and were also recognized by T cells of the individuals studied. These results suggest that these paramyosin peptides are promising antigens to compose an anti-schistosomiasis vaccine.

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Focus: Schistosomiasis

Cited by 243 publications

References 21 publications

IL-4 and IFN-γ induced by human immunodeficiency virus vaccine in a schistosome infection model

IL-4 and IFN-γ induced by human immunodeficiency virus vaccine in a schistosome infection model

Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection

Identification of paramyosin T cell epitopes associated with human resistance toSchistosoma mansonireinfection

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