Focused ion beam irradiation platform with a 3-D fluorescence imaging system: a flexible tool for cancer research
Andrew Harken,
Naresh Deoli,
Citlali Perez Campos
et al.
Abstract:To improve particle radiotherapy, we need a better understanding of the biology of targeted and non-targeted radiation effects. This is particularly important in the field of heavy ion radiation therapy where global effects are observed, yet only a subset of cells receive a high energy deposition from ion tracks. To allow real-time 3D imaging of living biological samples during and after irradiation with a focused ion beam, we have integrated a high-speed light sheet fluorescence imaging system (swept confocal… Show more
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