Focusing lung transplant: physiological and antioxidant responses and effect of allopurinol to ischemia-reperfusion oxidative stress under different inspired oxygen concentrations

Abstract

Background: To evaluate the effect of alopurinol after lung ischemia-reperfusion (IR) injury under ventilation with different inspired oxygen concentrations (0.21 and 1.00 pO2) on physiological responses and tissue damage and antioxidants present in lung parenchyma.