FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: Evidence through a meta-analysis

Yadav, Upendra; Kumar, Pradeep; Rai, Vandana

doi:10.1016/j.meegid.2021.104871

Cited by 9 publications

(4 citation statements)

References 78 publications

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“…However, the genetic variations in Taq1 seemed to play no role [55]. Upendra Yadav et al discovered a significant association between FokI and TB susceptibility in the overall analysis and the Asian population [56]. Sudhasini Panda et al demonstrated a considerable association between the Fok1 SNP (f allele) and susceptibility to TB [57].…”

Section: Vitamin D Levels and Afb Gradingmentioning

confidence: 99%

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Mamadapur,

Nagaraju,

Prabhu

2024

Medicina

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Background and Objectives: Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis, a member of the Mycobacterium tuberculosis complex. It contributes to significant morbidity and mortality. Treatment of TB poses a considerable challenge because of emerging drug resistance and the longer duration of therapy. Various past studies, both in vitro and in vivo, have established the role of vitamin D in the pathogenesis and treatment of TB. Results of in vivo studies are inconsistent, and this study aims to determine vitamin D levels and their association with newly diagnosed TB (pulmonary and extrapulmonary) cases and normal populations. Material and Methods: A Prospective Case-Control study with 116 subjects (58 cases and 58 controls) was conducted over two years. 29 cases of pulmonary TB and 29 cases of extrapulmonary TB constituted 58 cases of TB. Vitamin D levels were measured and compared in both the cases and controls. Data analysis was carried out using SPSS software 22.0. Results: The prevalence of vitamin D deficiency was 68.96% in the cases, while it was 51.72% in the controls. The reported median and quartile of serum vitamin D levels were 14.35 ng/mL (8.65, 25.48) in the TB group and 19.08 ng/mL (13.92, 26.17) in the control group. There was a significant statistical difference between the TB and non-TB populations with a p-value of 0.029 on the Mann–Whitney test. Conclusion: Vitamin D deficiency was more prevalent in individuals with TB than those without TB.

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Section: Vitamin D Levels and Afb Gradingmentioning

confidence: 99%

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Mamadapur,

Nagaraju,

Prabhu

2024

Medicina

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“…Growing evidence has demonstrated that vitamin D receptor (VDR) SNVs are involved in the pathogenesis of several inflammatory disorders, such as fracture-related infection[ 73 ], tuberculosis[ 74 ], and periodontitis[ 75 ]. In a 2017 study, Soroush et al [ 76 ] analyzed the role of VDR SNV rs2228570 in the development of DFU in an Iranian population.…”

Section: Genetic Snvs Involved In Dfu Developmentmentioning

confidence: 99%

Single nucleotide variations in the development of diabetic foot ulcer: A narrative review

Hu¹,

Song²,

Jiang³

2022

World J Diabetes

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Diabetes mellitus has become a global health problem, and the number of patients with diabetic foot ulcers (DFU) is rapidly increasing. Currently, DFU still poses great challenges to physicians, as the treatment is complex, with high risks of infection, recurrence, limb amputation, and even death. Therefore, a comprehensive understanding of DFU pathogenesis is of great importance. In this review, we summarized recent findings regarding the DFU development from the perspective of single-nucleotide variations (SNVs). Studies have shown that SNVs located in the genes encoding C-reactive protein, interleukin-6, tumor necrosis factor-alpha, stromal cell-derived factor-1, vascular endothelial growth factor, nuclear factor erythroid-2-related factor 2, sirtuin 1, intercellular adhesion molecule 1, monocyte chemoattractant protein-1, endothelial nitric oxide synthase, heat shock protein 70, hypoxia inducible factor 1 alpha, lysyl oxidase, intelectin 1, mitogen-activated protein kinase 14, toll-like receptors, osteoprotegerin, vitamin D receptor, and fibrinogen may be associated with the development of DFU. However, considering the limitations of the present investigations, future multi-center studies with larger sample sizes, as well as in-depth mechanistic research are warranted.

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“…The VDR gene is positioned on chromosome 12 that extents around 75 kb of genomic DNA and comprises 11 exons [6]. An ongoing argument on global VDD and the presence of VDR in reproductive tissues with an increased prevalence of infertility has encouraged us to conduct the study.…”

Section: Introductionmentioning

confidence: 99%

Identification of a Single Nucleotide Polymorphism of Vitamin D Receptor (VDR) and Vitamin D Binding Protein (VDBP) Gene and Its Dysregulated Pathway Through VDR-VDBP Interaction Network Analysis in Vitamin D-Deficient Infertile Females

Rubab,

Naz,

Ashraf

et al. 2024

Cureus

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Introduction: The prevalence of female infertility in Pakistan is currently estimated at 22%, and emerging research suggests that vitamin D (VD) deficiency (VDD) may play a significant role in influencing female fertility. The focus of this study was to investigate the single nucleotide polymorphism (SNP) patterns within the VD binding protein (VDBP). The study aimed to explore dysregulated pathways and gene enrichment through an interaction network analysis, specifically focusing on the interplay between the VD receptor (VDR) and VDBP in females experiencing unexplained infertility (UI) coupled with VDD.Methods: A cross-sectional study was conducted on VD-deficient, fertile, and UI female subjects. VDBP and VDR were assessed by enzyme-linked immunoassay and genotyping performed. FunRich (version 3.1.3; http://funrich.org/index.html) was employed for analysis of the identified proteins: VDR and VDBP and with their mapped gene datasets, gene enrichment, and protein-protein interaction (PPI) network.Results: The mean VD and VDR values of infertile females were significantly lower than those of fertile females. VDBP in infertile females (median (IQR)): 296.05 (232.58-420.23)) was lower than that of fertile females (469.9 (269.57-875.55), (p=0.01)). On sequence analysis, a mutation rs 4588 SNP (Thr 436 Lys) was found in exon 11 of the VDBP gene of UI females, but no mutation in exons 8 and 9 of the VDR gene, with some insignificant intronic variants, was observed. The proteins such as plasma membrane estrogen receptor signaling pathway (p < 0.001), VDR, SMAD3, NCOR1, CREBBP, NCOA1, STAT1, GRB2, PPP2CA, TP53, and NCOA2 were enriched after biological pathway grouping when VDR was made the focused gene and directly interacting with VDBP. Conclusion:The females with UI exhibited significantly low VD, VDBP, and VDR. The plasma membrane estrogen receptor signaling pathway was enriched in VDD infertile females.

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FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: Evidence through a meta-analysis

Cited by 9 publications

References 78 publications

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Single nucleotide variations in the development of diabetic foot ulcer: A narrative review

Identification of a Single Nucleotide Polymorphism of Vitamin D Receptor (VDR) and Vitamin D Binding Protein (VDBP) Gene and Its Dysregulated Pathway Through VDR-VDBP Interaction Network Analysis in Vitamin D-Deficient Infertile Females

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