Folate and choline absorption and uptake: Their role in fetal development

Radziejewska, Anna; Chmurzyńska, Agata

doi:10.1016/j.biochi.2018.12.002

Cited by 41 publications

(36 citation statements)

References 121 publications

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“…During pregnancy, choline requirements rise due to increased maternal demands and rapid division of fetal cells. The availability of choline to cells will depend on food intake, its absorption, and the efficacy of cellular transport systems [46]. As de novo synthesis by the human body may become insufficient, choline is an essential dietary component [21].…”

Section: Accruementmentioning

confidence: 99%

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire

Obeid

2020

Nutrients

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The foundations of neurodevelopment across an individual’s lifespan are established in the first 1000 days of life (2 years). During this period an adequate supply of nutrients are essential for proper neurodevelopment and lifelong brain function. Of these, evidence for choline has been building but has not been widely collated using systematic approaches. Therefore, a systematic review was performed to identify the animal and human studies looking at inter-relationships between choline, neurological development, and brain function during the first 1000 days of life. The database PubMed was used, and reference lists were searched. In total, 813 publications were subject to the title/abstract review, and 38 animal and 16 human studies were included after evaluation. Findings suggest that supplementing the maternal or child’s diet with choline over the first 1000 days of life could subsequently: (1) support normal brain development (animal and human evidence), (2) protect against neural and metabolic insults, particularly when the fetus is exposed to alcohol (animal and human evidence), and (3) improve neural and cognitive functioning (animal evidence). Overall, most offspring would benefit from increased choline supply during the first 1000 days of life, particularly in relation to helping facilitate normal brain development. Health policies and guidelines should consider re-evaluation to help communicate and impart potential choline benefits through diet and/or supplementation approaches across this critical life stage.

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Section: Accruementmentioning

confidence: 99%

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire

Obeid

2020

Nutrients

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“…Choline is also required to synthesize phospholipids including phosphatidylcholine and sphingomyelin, both of which are essential components of cell membranes. During pregnancy, the requirements for choline increase because of elevated maternal demand and the rapid division of fetal cells [28]. Choline can also influence stem cell proliferation and choline insufficiency can promote cellular apoptosis.…”

Section: Cholinementioning

confidence: 99%

Nutritional Gaps and Supplementation in the First 1000 Days

Korczak²,

et al. 2019

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Optimized nutrition during the first 1000 days (from conception through the 2nd birthday) is critical for healthy development and a healthy life for the newborn. Pregnancy and the postpartum period are accompanied by physiological changes, increased energy needs, and changing requirements in the nutrients critical for optimal growth and development. Infants and toddlers also experience physiological changes and have specific nutritional needs. Food and nutrition experts can provide women of childbearing age with adequate dietary advice to optimize nutrition, as well as guidance on selecting appropriate dietary supplements. Considering the approaching 2020–2025 Dietary Guidelines for Americans (DGA) will be making specific recommendations for children, it is important to provide accurate scientific information to support health influencers in the field of nutrition. The purpose of this review is to summarize the nutrition and supplementation literature for the first 1000 days; to highlight nutritional and knowledge gaps; and to educate nutrition influencers to provide thoughtful guidance to mothers and families. Optimal nutrition during pregnancy through early childhood is critical for supporting a healthy life. Nutrition influencers, such as dietitians, obstetricians/gynecologists, and other relevant health professionals, should continue guiding supplement and food intake and work closely with expectant families and nutrition gatekeepers.

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“…Furthermore, findings in rodents show that choline deficiency can promote heart dysfunction [13]. Also, pregnant women should ensure adequate levels of choline due to its importance in fetal development [14].…”

Section: Introductionmentioning

confidence: 99%

Plasma Kinetics of Choline and Choline Metabolites After A Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers

et al. 2019

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As an essential nutrient, the organic water-soluble compound choline is important for human health. Choline is required for numerous biological processes, including the synthesis of neurotransmitters, and it is an important prerequisite for structural integrity and the functioning of cells. A choline-rich diet provides crucial choline sources, yet additional choline dietary supplements might be needed to fully meet the body’s requirements. Dependent on the structure of choline in different sources, absorption and metabolism may differ and strongly impact the bioavailability of circulating choline. This study in healthy volunteers aimed to compare the pharmacokinetics of free choline and of selected choline metabolites between the single dose intake of phosphatidylcholine, present in SuperbaBoostTM krill oil, and choline bitartrate salt. Results demonstrate that albeit free choline levels in plasma were comparable between both choline sources, peak choline concentration was reached significantly later upon intake of SuperbaBoostTM. Moreover, the occurrence of choline metabolites differed between the study products. Levels of the biologically important metabolites betaine and dimethylglycine (DMG) were higher, while levels of trimethylamine N-oxide (TMAO) were substantially lower upon intake of SuperbaBoostTM compared to choline bitartrate.

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Folate and choline absorption and uptake: Their role in fetal development

Cited by 41 publications

References 121 publications

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Nutritional Gaps and Supplementation in the First 1000 Days

Plasma Kinetics of Choline and Choline Metabolites After A Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers

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