Folate deficiency enhances the inflammatory response of macrophages

Kolb, Andreas; Petrie, Linda

doi:10.1016/j.molimm.2012.11.012

Cited by 71 publications

(51 citation statements)

References 45 publications

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“…The insufficiency of folic acid has long been known to be related to certain diseases such as neural tube defects in fetus and megaloblastic anaemia (Heseker, 2011). Other ailments associated with low levels of folic acid range from nervous system disturbances to cardiovascular disorders and cancer (Iyer & Tomar, 2009;Kolb & Petrie, 2013). It is assumed that on a population level, nutritional requirements for folate cannot be completely covered by a varied diet, as recommended by national health authorities (Iyer & Tomar, 2009).…”

Section: Introductionmentioning

confidence: 99%

Casein nanoparticles as carriers for the oral delivery of folic acid

et al. 2015

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Alimentary proteins can be viewed as an adequate material for the preparation of nanoparticles and microparticles. They offer several advantages such as their digestibility, price and a good capability to interact with a wide variety of compounds and nutrients. The aim of this work was to prepare and characterize casein nanoparticles for the oral delivery of folic acid. These nanoparticles were prepared by a coacervation process, stabilized with either lysine or arginine and, finally, dried by spray-drying. For some batches, the effect of a supplementary treatment of nanoparticles (before drying) with hydrodynamic high pressure on the properties of the resulting carriers was also evaluated. The resulting nanoparticles displayed a mean size close to 150 nm and a folic acid content of around 25 mg per mg nanoparticle. From the in vitro release studies, it was observed that casein nanoparticles acted as gastro-resistant devices and, thus, folic acid was only released under simulated intestinal conditions. For the pharmacokinetic study, folic acid was orally administered to laboratory animals as a single dose of 1 mg/kg. Animals treated with folic acidloaded casein nanoparticles displayed significantly higher serum levels than those observed in animals receiving an aqueous solution of the vitamin. As a consequence the oral bioavailability of folic acid when administered in casein nanoparticles was calculated to be around 52%, a 50% higher than with the traditional aqueous solution. Unfortunately, the treatment of casein nanoparticles by hydrodynamic high pressure modified neither the release profile of the vitamin nor its oral bioavailability.

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Section: Introductionmentioning

confidence: 99%

Casein nanoparticles as carriers for the oral delivery of folic acid

et al. 2015

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“…Folate deficiencies can lead to elevated homocysteine levels. Elevated homocysteine levels are linked with increased inflammation . Similar results were seen with folate; it was observed that 10% of head and neck cancers were due to the interaction between low folate and smoking .…”

Section: Discussionmentioning

confidence: 67%

Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer

Mazul

Shivappa

Hébert

et al. 2018

Intl Journal of Cancer

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Diets high in fruits and vegetables and low in red meat intake have been associated with decreased risk of head and neck cancer. Additionally, chronic inflammation pathways and their association with cancer have been widely described. We hypothesized a proinflammatory diet, as measured by the dietary inflammatory index (DII ), is associated with increased risk of head and neck cancer. We used the Carolina Head and Neck Cancer (CHANCE) study, a population-based case-control study of head and neck squamous cell carcinoma. Cases were recruited from a 46-county region in central North Carolina. Controls, frequency-matched on age, race, and sex were identified through the North Carolina Department of Motor Vehicle records. The DII score, adjusted for energy using the density approach (E-DII), was calculated from a food frequency questionnaire and split into four quartiles based on the distribution among controls. Adjusted odds ratios (ORs) were estimated with unconditional logistic regression. Cases had higher E-DII scores (i.e., a more proinflammatory diet) compared with controls (mean: -0.14 vs. -1.50; p value < 0.001). When compared with the lowest quartile, the OR for the highest quartile was 2.91 (95% confidence interval (CI): 2.16-3.95), followed by 1.93 (95% CI: 1.43-2.62) for the third quartile, and 1.37 (95% CI: 1.00-1.89) for the second quartile. Both alcohol and smoking had a significant additive interaction with E-DII (smoking relative excess risk due to interaction (RERI): 2.83; 95% CI: 1.36-4.30 and alcohol RERI: 1.75; 95% CI: 0.77-2.75). These results provide additional evidence for the association between proinflammatory diet and head and neck cancer.

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“…Folate is a B vitamin that is synthesised in plants and is essential for human health due to its role in synthesising, repairing and methylating DNA . Folate deficiency is associated with neural tube defects non‐alcoholic fatty liver disease and steatohepatitis, and it is a risk factor for vascular disease . The cells in the human body are unable to synthesise folate so there must be sufficient dietary intake .…”

Section: Discussionmentioning

confidence: 99%