Folate intake, plasma folate and homocysteine status in a random Finnish population

Alfthan, Georg; Laurinen, M S; Valsta, Liisa; Pastinen, Tomi; A, Aro

doi:10.1038/sj.ejcn.1601507

Cited by 59 publications

(47 citation statements)

References 45 publications

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“…Hcy level in males was consistently higher than in females (Table 2), more strikingly in cases of hypHcy. Compared with non-vegetarians, hypHcy was significantly higher in vegetarians, and in non-vegetarian females it was even lower, showing a gender and dietary bias towards hypHcy (data not shown), as earlier documented (Alfthan et al, 2003;Elmadfa and Singer, 2009).…”

Section: Resultssupporting

confidence: 67%

Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population

Sukla

Raman

2011

Eur J Clin Nutr

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Background/Objectives: Unlike most Western populations, MTHFR 677T is a rare allele and a risk factor for a variety of disorders in India. What kind of nutritional (environmental) and/or genetic factors could contribute to the genetic risk is not known. To assess the incidence of hyperhomocysteinemia and its correlation with the polymorphism in homocysteine (Hcy)-pathway genes and associated cofactors in the native populations of eastern India. Subjects/Methods: Healthy population from four eastern states of India. Genotyping of SNPs, HPLC and chemiluminescencebased assay for homocysteine, vitamin B12 and folic acid.Results: Approximately 30% of the population has hyperhomocysteinemia (415 mmol/lit; hypHcy) with varying frequencies in the four states from where samples were collected (n ¼ 1426). Polymorphisms of MTR and CBS do not affect hypHcy. 677T and 1298C alleles of MTHFR and G80 RFC-1 show association with hypHcy. In contrast, RFC-1 80AA is protective even in presence of 677T MTHFR. Addition of each mutant allele has an additive effect on Hcy level. Vitamin B12 (cofactor in methionine synthesis) clearly modulates the genotypic effect on Hcy level. Although frequency of individuals with low folic acid is B11, 49% of the population is vitamin B12 deficient (o220 pg/lit) and has a significant negative correlation with Hcy. Individuals with optimum vitamin B12 and folic acid generally have low Hcy, even in risk genotypes. Conclusions: One of the plausible reasons for susceptibility of individuals with MTHFR C677T in the studied population to various disorders is the high frequency of hyperhomocysteinemia and vitamin B12 deficiency in the 'healthy population'. Apparently, supplementation of vitamin B 12 to this health-impoverished community may help lessen the risk of several multifactorial disorders.

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Section: Resultssupporting

confidence: 67%

Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population

Sukla

Raman

2011

Eur J Clin Nutr

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“…This percentage is much higher than in the US population , in which a lower cutoff point was applied (411.4 mmol/l in men and 410.4 mmol/l in women), and in the Finnish population (Alfthan et al, 2003) with a 14 mmol/l cutoff point.…”

Section: Discussionmentioning

confidence: 79%

Nutritional determinants of plasma total homocysteine distribution in the Canary Islands

et al. 2006

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Objective: We sought to define plasma homocysteine reference values in healthy individuals in the Canary Islands and to determine its relations to folate and vitamin B12 intakes and concentrations. Design: Cross-sectional study. Setting: Population-based representative sample of 557 participants, aged 18-65 years, from the Canary Islands Nutrition Survey (ENCA). Subjects: All participants completed two 24-h dietary recalls and a general questionnaire collecting socio-demographic and health-related lifestyle information. Interventions: Plasma homocysteine and serum vitamin B12 levels were measured by immunoassay, whereas folate levels through an automated ionic capturing method. Results: Median plasma homocysteine was 11.9 mmol/l, higher in men (13.1 mmol/l) than in women (10.9 mmol/l) (Po0.001) and positively associated with age in both sexes (Po0.001). The prevalence of hyperhomocysteinaemia (X15 mmol/l), 21.4%, was also greater in men (32.2%) than in women (13.4%). There were significant negative correlations between plasma homocysteine and serum (r ¼ À0.32, Po0.001) and erythrocyte (r ¼ À0.26, Po0.001) folate, as well as serum vitamin B12 (r ¼ À0.28, Po0.001) concentrations. When divided in quartiles of vitamin intakes or concentrations, men with the lowest vitamin B12 and folate serum values had significantly higher plasma homocysteine concentrations than those in the other three quartiles. In women, hyperhomocysteinaemia was higher in the lowest quartiles of folate intake and serum and erythrocyte folate concentrations. Conclusions: These data provide further evidence that hyperhomocysteinaemia is a sensitive marker of inadequate folate and vitamin B12 status, allowing for the identification of those with greatest need for nutritional interventions.

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“…Therefore, the intake of vitamin D from all kind of supplements was calculated. The dietary supplement database used was based on the database of the National Public Health Institute (Alfthan et al, 2003), to which new dietary supplements were added. Maternal age, maternal and paternal occupation, length of education, number of children in the family and place of residence were asked by a structured questionnaire (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Intake of vitamin D by Finnish children aged 3 months to 3 years in relation to sociodemographic factors

et al. 2006

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Objective: To study the total daily intake of vitamin D from food and supplements among Finnish children aged 3 months to 3 years, the dietary sources of vitamin D and the association between vitamin D intake and sociodemographic factors. Subjects and methods: The subjects are participants in the Finnish Type I Diabetes Prediction and Prevention Nutrition Study born between October 1997 and October 1998. At the age of 3 and 6 months, 1, 2 and 3 years, 342 (72% of the invited families), 298 (63%), 267 (56%), 233 (49%) and 209 (44%) families, respectively, participated in the present study. Food consumption was assessed by a 3-day food record. A structured questionnaire was used to record the parents' socioeconomic status. Results: The mean dietary vitamin D intake exceeded the recommendation (10 mg/day) at the age of 3 (11.0 mg) and 6 months (12.0 mg), but decreased thereafter being 9.8, 5.0 and 4.1 mg at 1, 2 and 3 years of age, respectively. Among the children 91, 91, 81, 42 and 26% used vitamin D supplements at the age of 3 and 6 months, and 1, 2 and 3 years, respectively. In children not using vitamin D supplements, vitamin D intake was less than 10 mg/day at all ages. Vitamin D intake from food did not differ in children who used and did not use vitamin D supplements. Vitamin D supplements were the main source of vitamin D intake in all age groups studied, followed by vitamin D-fortified infant formula in 3-month-olds and infant formula and baby foods in 6-month-olds. After the age of 1 year, the most important food sources of vitamin D were margarine, fish, baby foods, low-fat milk and eggs. Sociodemographic factors, especially the number of children in the family and maternal age, were associated with the total vitamin D intake and vitamin D supplement use. Conclusion: Vitamin D supplements are not used according to the dietary recommendations in a substantial proportion of Finnish children.

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Folate intake, plasma folate and homocysteine status in a random Finnish population

Cited by 59 publications

References 45 publications

Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population

Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population

Nutritional determinants of plasma total homocysteine distribution in the Canary Islands

Intake of vitamin D by Finnish children aged 3 months to 3 years in relation to sociodemographic factors

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