Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

Chen, Dongming; Dong, Jun; Huang, Ying; Gao, Feng; Yang, Xiaopeng; Gong, Xianglun; Lv, Xiaochen; Chu, Chenghao; Wu, Yifeng; Zheng, Ye

doi:10.18632/oncotarget.18986

Cited by 8 publications

(9 citation statements)

References 40 publications

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“…A meta-analysis was conducted to evaluate the impact of the MTHFR A1298C polymorphism on meningioma and glioma risk [ 118 ]. The analyses included 5 case-control studies with 2997 cases and 3403 controls.…”

Section: Mthfr C677t and A1298c Polymorphisms And Gliomamentioning

confidence: 99%

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

Petrone

Bernardo

Santos

et al. 2021

Genes

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Folate (vitamin B9) is found in some water-soluble foods or as a synthetic form of folic acid and is involved in many essential biochemical processes. Dietary folate is converted into tetrahydrofolate, a vital methyl donor for most methylation reactions, including DNA methylation. 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine. MTHFR polymorphisms result in reduced enzyme activity and altered levels of DNA methylation and synthesis. MTHFR polymorphisms have been linked to increased risks of several pathologies, including cancer. Breast cancer, gliomas and gastric cancer are highly heterogeneous and aggressive diseases associated with high mortality rates. The impact of MTHFR polymorphisms on these tumors remains controversial in the literature. This review discusses the relationship between the MTHFR C677T and A1298C polymorphisms and the increased risk of breast cancer, gliomas, and gastric cancer. Additionally, we highlight the relevance of ethnic and dietary aspects of population-based studies and histological stratification of highly heterogeneous tumors. Finally, this review discusses these aspects as potential factors responsible for the controversial literature concerning MTHFR polymorphisms.

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Section: Mthfr C677t and A1298c Polymorphisms And Gliomamentioning

confidence: 99%

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

Petrone

Bernardo

Santos

et al. 2021

Genes

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“…Several experimental and epidemiological study results have connected disorders of folate metabolism of homocysteine to vascular, neurodegenerative, neuropsychiatric, and neoplastic disease, including not only strokes, but also Parkinson’s disease, Alzheimer disease, and glioma [14, 36, 37, 38, 39, 40]. Moreover, methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for in the folate metabolism of homocysteine.…”

Section: Discussionmentioning

confidence: 99%

The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer’s disease

Xiao

Zhou

et al. 2019

Open Medicine

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AbstractFolate metabolism makes a crucial contribution towards late-onset Alzheimer’s disease (LOAD). Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. We hypothesize that there is an association of C677T polymorphism in the MTHFR gene with the susceptibility to LOAD. Previous published research has investigated the link between the MTHFR C677T polymorphisms and LOAD susceptibility; nevertheless, the findings have continued to be not only controversial, but also indecisive. Accordingly, we carried out the present meta-analysis for the assessment of the potential link that exists between the MTHFR C677T polymorphism and the susceptibility to LOAD. Furthermore, we carried out a literature search of the PubMed, EMBASE, Cochrane Library, and WanFang database up to August 10, 2018. The odds ratios (ORs) with the respective 95% confidence interval (95%CI) were put to use for the evaluation of the robustness of the link of the MTHFR C677T polymorphism with the vulnerability to LOAD. All statistical analyses were carried out using STATA 15.0. An aggregate of 14 case-control research works was retrieved, involving 2,467 LOAD patients as well as 2,877 controls. We found that a substantial link exists between C677T polymorphism and LOAD risk in a codominant framework (TC vs. CC: OR=1.22, 95%CI=1.00-1.49, P=0.049). In addition to the stratified analysis based on ethnicity, which suggested that C677T polymorphism was likely linked only to an augmented threat of LOAD in Asians, it did not exist among Caucasians. Furthermore, in the subgroup analysis carried out using APOE ɛ4 status, a substantial increase in the susceptibility to LOAD was detected in APOE ɛ4 carriers as well as non-APOE ɛ4 carriers. In sum, the current meta-analysis revealed that MTHFR C677T polymorphism was associated with susceptibility to LOAD. Further extensive case-control studies are required.

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“…Estudos de associação genética visam investigar o possível relacionamento entre diferentes variantes polimórficas como fatores de risco ou proteção em doenças, notadamente no câncer, incluindo gliomas (Bethke et al, 2008;Zhang et al, 2013;Chen et al, 2017 Ao contrário das células normais, as células tumorais quando privadas de metionina interrompem o ciclo celular na fase S/G2, ficando mais susceptíveis aos agentes quimioterápicos (Hoffman, 2015;Palanichamy et al, 2016).…”

Section: Polimorfismos Funcionais Em Componentes Da Via Do Folatounclassified

Risco De Acidente Vascular Encefálico Em Mulheres Jovens Relacionado Ao Uso Do Contraceptivo Oral

Xavier¹,

Azevedo²

2019

Difusão Do Conhecimento Através Das Diferentes Áreas Da Medicina 2

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Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

Cited by 8 publications

References 40 publications

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer’s disease

Risco De Acidente Vascular Encefálico Em Mulheres Jovens Relacionado Ao Uso Do Contraceptivo Oral

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