Folate-PEG coated cationic modified chitosan – Cholesterol liposomes for tumor-targeted drug delivery

A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

“…That might be owing to the limited FRs expression on C6 cells. 4 In the competition assay, the uorescence intensity of cells incubated with G4-FA-PEG/DOX was reduced aer presaturation with free FA (62.44 for B2), illustrating that the decreased cellular uptake of G4-FA-PEG/DOX was due to the competitively binding of free FA with FRs on the C6 cell, [42][43][44] which further conrmed the targeting effect of FA to C6 cells through FRmediated endocytosis.…”

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

“…96,[100][101][102][103][104][105][106][107] The nanoparticles (NPs) are mainly prepared via the dispersion of preformed polymers, the polymerization of monomers, ionic gelation, or the coacervation of hydrophilic polymers, but other methods for their generation have also been reported, such as supercritical fluid technology and particle replication in non-wetting templates (PRINT ® ; DeSimone Lab, Chapel Hill, NC, USA). [108][109][110][111][112][113][114] NPs can improve the stability of drugs and control their targeted delivery, allowing for a constant and uniform concentration at the site of a lesion and facilitating drug extravasation into the tumor system, thus reducing side effects. [115][116][117] Damascelli et al evaluated the effectiveness of the intraarterial infusion of paclitaxel incorporated in NPs based on human albumin (albumin NPs) for use as induction chemotherapy before definitive advanced tongue cancer treatment.…”

Paclitaxel-Loaded, Folic-Acid-Targeted and TAT-Peptide-Conjugated Polymeric Liposomes: In Vitro and In Vivo Evaluation

“…OQLCS and FA-OQLCS were synthesized in our laboratory as previously described in the literature (26). TAT peptide of the sequence Tyr-Gly-Arg-Lys-Lys-Arg-Arg-GlnArg-Arg-Arg (MW 1,560 Da) was synthesized by GL Biochem Ltd. (Shanghai, China).…”

“…Preparation of FA-PLs FA-PLs were prepared using the thin-film hydration method as described previously (26,27). In brief, FA-OQLCS, OQLCS and cholesterol (w/w/w 1:1:1 total weight 20 mg) were dissolved in chloroform.…”