Folate–PEG functionalized silica CdTe quantum dots as fluorescent probes for cancer cell imaging

Lü, Miao; Zhang, Wendian; Gai, Yongkang; Tan, Yang; Ye, Peng; Yang, Guang; Ma, Xiang; Xiang, Guangya

doi:10.1039/c4nj00416g

Cited by 18 publications

(12 citation statements)

References 36 publications

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“…QD-silica nanoparticles so far described involve the coating of quantum dots with solid silica, 15,16,17,18,19,20,21 while scarce examples of QDs covered with mesoporous silica nanoparticles (MNs) have been described 22 . In those cases, most often QDs are embedded into the mesoporous, bringing down any other possibility to further encapsulate active drugs or active components.…”

Section: Introductionmentioning

confidence: 99%

Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers

et al. 2019

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“…33 Compared with aforementioned red fluorescent nanoparticles, these GCC NPs demonstrated outstanding advantages in their economic values and bioapplications, such as low cost, robust preparation procedure, favorable deep red emission, and excellent anti-photobleaching property. [36][37][38][39][40][41][42] More importantly, the PEGylation of 20 nanoparticles would guarantee them the superb biocompatibility. Nevertheless, the positive charges on GCC NPs, which endowed them the intense red fluorescence, also brought some problems, for examples, reduced biocompatibility and short circulation time in biological 10 systems.…”

Section: Introductionmentioning

confidence: 99%

Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

et al. 2015

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PEGylated red fluorescent nanoparticles with excellent biocompatibility and photostablity were facilely prepared from nonluminous materials: first red fluorescent nanoparticles (GCC NPs) were robustly prepared from chitosan and glutaraldehyde; then the amino groups and hydroxyl groups on GCC NPs surface were modified with 2-bromoisobutyryl bromide to get the GCC-Br, which was employed as the nanoparticles initiator in ATRP system to finally obtain the GCC-poly(PEGMA) conjugates. The resulted GCC-poly(PEGMA) can emit biofavorable deep red luminescence, which was quite stable and anti-photobleaching. Furthermore, GCC-poly(PEGMA) demonstrated excellent biocompatibility and water dispersibility due to the PEGMA chains conjugated on the surface; and the abundant hydroxyl groups on the surface can be further functionalized with diverse other groups or large biomolecules. This construction method demonstrated huge superiorities in its simple strategy and economic value, and their successful cellular imaging applications made them highly potential for various biomedical applications. Abstract Biocompatible and photostable PEGylated red fluorescent nanoparticles were prepared via surface-initiated ATRP and their cellular imaging application was successfully demonstrated.

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“…Lu et al. used folate ligand‐modified silica‐coated cadmium telluride QDs (CdTe QDs) as fluorescent nanoprobes for targeted imaging of folic acid receptors in KB carcinoma cells . Cheng et al.…”

Section: Methodsmentioning

confidence: 99%

Small‐Protein‐Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells

et al. 2016

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Recently, semiconductor nanoparticles such as quantum dots (QDs) have attracted significant attention for bioimaging. Complex chemical functionalization, surface modification, and bioconjugation chemistry are generally required to tag biomolecules to QDs for imaging of different biomarkers. In this study, we report a simple method for production of QDs stabilized by the small protein, Affibody (AF-QDs) for fluorescent imaging of the human epidermal growth factor receptor type 2 (HER2) in human A549 lung cancer cells. This one-pot synthesis of AF-QDs avoids complex chemical conjugation procedures and demonstrates a promising approach for the preparation of fluorescent nanoprobes for imaging of cancer targets.

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Folate–PEG functionalized silica CdTe quantum dots as fluorescent probes for cancer cell imaging

Abstract: CdTe@SiO2–NH–CO–PEG−folate nanoparticles were successfully prepared and demonstrated tumor cell specific targeting through folate receptors via folate mediated endocytosis.

Cited by 18 publications

References 36 publications

Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers

Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers

Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

Small‐Protein‐Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells

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