Folic acid conjugated amine functionalized cerium oxide nanoparticle for cancer targeted gene therapy

Krishnan, Harini; Vinothkumar, G.; Suresh, B.; Sant, Vinayak; Shilpa, Sant

doi:10.3389/conf.fbioe.2016.01.02364

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this way, chitosan directly forms complexes with negatively charged DNA molecules due to the positive charge of the polymer, while for the other polymers such DNA complexes can be formed indirectly, via binding with inorganic nanoparticles, for example, positively charged nanoparticles of cerium oxide. It is well known that cerium compounds (including CeNPs) can perform the function of a restriction enzyme [ 19 ] and actively promote transfection in gene therapy [ 19 , 98 ]. Hasanzadeh et al synthesized CeNPs-containing polyethylenimine (PEI) nanoparticles (124 ± 7 nm, ζ-potential 22 ± 2 mV) as a novel and promising gene delivery vector pDNA-PEI-CeO 2 [ 99 ].…”

Section: Polymeric Composites With Ceria Nanoparticles For Drug Dementioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

View full text Add to dashboard Cite

The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

show abstract