Folic acid conjugated PEG coated gold–iron oxide core–shell nanocomplex as a potential agent for targeted photothermal therapy of cancer

Ghaznavi, Habib; Hosseini-Nami, Samira; Kamrava, Seyed Kamran; Irajirad, Rasoul; Maleki, Shayan; Shakeri‐Zadeh, Ali; Montazerabadi, Alireza

doi:10.1080/21691401.2017.1384384

Cited by 59 publications

(44 citation statements)

References 41 publications

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“…Similarly, in previous in vitro and in vivo studies, gold nanoparticles have been used as tool both to detect and to treat breast cancer [45]. Indeed, the mostly used strategies were the ones coupling the hyperthermia effect with selective functionalization systems to optimize the cytotoxicity [46].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity Study of Gold Nanoparticles on the Basal-Like Triple-Negative HCC-1937 Breast Cancer Cell Line

Massard¹,

Dubois²,

Raspal³

et al. 2018

JBNB

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The Triple Negative "Basal-like" breast cancer (TNBL) tumours have a high proliferative capacity and develop a resistance phenotype associated with metastases. However, the management of TNBL carcinomas is still not standardized. Among the promising trails, gold nanoparticles could be a relevant tool for the development of a targeted treatment for this breast cancer subtype in monotherapy, associated and/or conjugated with other drugs. In this work, we report the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene Glycol (PEG) on the TNBL HCC-1937 breast cancer cell line. PEG-coated gold nanoparticles (PEG-Au NPs) were synthesized by a two-step method using a reduction process followed by a post-functionalization called PEGylation. PEG-Au NPs were characterized using transmission electron microscopy and X-ray diffraction. The gold content of the samples was determined using atomic absorption spectrometer. The cytotoxicity tests were performed using Sulforhodamine B survival test and resazurin viability test. PEG-Au NPs impact analysis on HCC1937 TNBL cell line showed a clear toxic action of type dose dependent and at long term. These PEGylated gold nanoparticles present a promising tool for the development of tumor-specific radiosensitizing vectors, with or without the association of other treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity Study of Gold Nanoparticles on the Basal-Like Triple-Negative HCC-1937 Breast Cancer Cell Line

Massard¹,

Dubois²,

Raspal³

et al. 2018

JBNB

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“…[31b,38] The popularity of gold nanoparticles can be attributed to their easy synthesis, targeting capability and favorable biocompatibility. [38c,d] In addition, gold nanoparticles display easy functionalization capability, allowing conjugation to different biological species including proteins and oligonucleotides[31b,41] via simple chemistry. For instance, Jon et al conjugated thiol‐modified CpG to gold nanospheres, creating photothermic and immunologic nanoparticles.…”

Section: Ptt‐synergized Immunotherapymentioning

confidence: 99%

Recent Progresses in Phototherapy‐Synergized Cancer Immunotherapy

2018

Adv Funct Materials

284

191

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Cancer immunotherapy has recently gained much attention in the search of cancer cure due to its ability to "train" the immune system in seeking out and removing residual tumor cells. However, relying on cancer immunotherapy alone may fail to ablate primary tumors. Phototherapy is a promising modality that offers an elegant solution to eradicate tumors through the simple application of light irradiation and meanwhile triggers immune responses by immunogenic cell death to enhance antitumor immunity. Uniting phototherapy with cancer immunotherapy has been found to achieve synergistic outcomes, promote cancer regression, and even attain immunologic memory. This review summarizes the recent studies on utilizing phototherapy and immunotherapy combinatorial approaches to treat cancer. A variety of nanoplatforms have been investigated in combination with immunoadjuvants and immune checkpoint blockades such as CTLA4 and PD-L1 pathways. Higher levels of proinflammatory cytokines, improved migration of dendritic cells, and an increased ratio of tumor-infiltrating cytotoxic T cells against regulatory T cells are revealedin many studies, offering a glimpse into the mechanistic principles. Future advancements targeting different cancer checkpoints that could offer better immunosuppression coupled with other phototherapeutic strategies remain to be explored in accomplishing complete elimination of cancer.

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“…The co‐incorporation of cisplatin and AuNPs within alginate hydrogel can improve their bioavailability and biocompatibility, while affording the opportunity for enhancement of chemoradiation due to synergistic interaction of cisplatin, AuNPs, and X‐ray. In the previous efforts, we tested the therapeutic effect of this nanocomplex on U87‐MG human glioblastoma cancer cells and CT26 mouse colon adenocarcinoma cells in vitro . In this study, we aim to assess the in vivo antitumor efficiency of this nanocomplex against CT26 colon adenocarcinoma tumor in the presence of 6 MV X‐ray.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of chemoradiation by co‐incorporation of gold nanoparticles and cisplatin into alginate hydrogel

et al. 2019

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Nonspecificity and high toxicity limit the treatment efficacy and safety of chemoradiation therapy. Effective tumor targeting of anticancer drugs and radiosensitizing agents is highly desirable to amplify the efficacy of this standard cancer therapy approach. To achieve this goal, we exploited the synergy of cisplatin and gold nanoparticles (AuNPs) co‐loaded into alginate hydrogel network, forming so‐called ACA nanocomplex, and X‐ray radiation. Cisplatin is a commonly used anticancer agent, and at the same time, along with AuNPs could function as radiosensitizers to enhance the radiation‐induced damages through various pathways. The ACA nanocomplex improved the therapeutic efficiency of standard chemotherapy and yielded 79% growth inhibition in CT26 colon adenocarcinoma tumor after 28 days, which was significantly higher than that of 9% for free cisplatin administration. Moreover, the combination of ACA nanocomplex with 6 MV X‐ray dramatically suppressed tumor growth up to 95%, showing 51% enhancement in antitumor activity compared to standard chemoradiation. The nanocomplex developed herein holds the promise to promote the efficiency of standard chemoradiation while maintaining the patient's safety through reducing the clinically administered doses of anticancer drug and X‐ray. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2658–2663, 2019.

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Folic acid conjugated PEG coated gold–iron oxide core–shell nanocomplex as a potential agent for targeted photothermal therapy of cancer

Cited by 59 publications

References 41 publications

Cytotoxicity Study of Gold Nanoparticles on the Basal-Like Triple-Negative HCC-1937 Breast Cancer Cell Line

Cytotoxicity Study of Gold Nanoparticles on the Basal-Like Triple-Negative HCC-1937 Breast Cancer Cell Line

Recent Progresses in Phototherapy‐Synergized Cancer Immunotherapy

Enhancement of chemoradiation by co‐incorporation of gold nanoparticles and cisplatin into alginate hydrogel

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