Folic acid enhances proinflammatory and antiviral molecular pathways in chicken B-lymphocytes infected with a mild infectious bursal disease virus

Uribe-Diaz, S; Nazeer, Nauman; Correa, Jairo Jaime; Vargas-Bermúdez, Diana S.; Yitbarek, Alexander; Ahmed, Marya; Rodríguez-Lecompte, J. C.

doi:10.1080/00071668.2021.1958298

Cited by 3 publications

(2 citation statements)

References 70 publications

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“…Folic acid supplementation modulated B lymphocyte responses and improved innate immune proinflammatory and antiviral response molecular pathways (Uribe-Diaz et al. 2022 ). It has preventive effects on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.…”

Section: Discussionmentioning

confidence: 99%

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

Chen

Wei

Qin

et al. 2022

Pharmaceutical Biology

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Context Coronavirus disease 2019 is a global pandemic. Studies suggest that folic acid has antiviral effects. Molecular docking shown that folic acid can act on SARS-CoV-2 Nucleocapsid Phosphoprotein (SARS-CoV-2 N). Objective To identify novel molecular therapeutic targets for SARS-CoV-2. Materials and methods Traditional Chinese medicine targets and virus-related genes were identified with network pharmacology and big data analysis. Folic acid was singled out by molecular docking, and its potential target SARS-CoV-2 N was identified. Inhibition of SARS-CoV-2 N of folic acid was verified at the cellular level. Results In total, 8355 drug targets were potentially involved in the inhibition of SARS-CoV-2. 113 hub genes were screened by further association analysis between targets and virus-related genes. The hub genes related compounds were analysed and folic acid was screened as a potential new drug. Moreover, molecular docking showed folic acid could target on SARS-CoV-2 N which inhibits host RNA interference (RNAi). Therefore, this study was based on RNAi to verify whether folic acid antagonises SARS-CoV-2 N. Cell-based experiments shown that RNAi decreased mCherry expression by 81.7% ( p < 0.001). This effect was decreased by 8.0% in the presence of SARS-CoV-2 N, indicating that SARS-CoV-2 N inhibits RNAi. With increasing of folic acid concentration, mCherry expression decreased, indicating that folic acid antagonises the regulatory effect of SARS-CoV-2 N on host RNAi. Discussion and conclusions Folic acid may be an antagonist of SARS-CoV-2 N, but its effect on viruses unclear. In future, the mechanisms of action of folic acid against SARS-CoV-2 N should be studied.

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Section: Discussionmentioning

confidence: 99%

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

Chen

Wei

Qin

et al. 2022

Pharmaceutical Biology

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“…Similar to the "developmental origins of health and disease" theory (12) , some scholars have noted that normal development of the foetal immunity as a potential advantageous intermediate outcome of adequate intrauterine folate might facilitate protective levels of immune response to vaccines after birth (13) . Previous work has shown that FAS is associated with an increase in levels of markers related to immunity, such as B lymphocyte response markers, innate immune proinflammatory pathways (14) , antigen processing and presentation markers, nuclear factor-k-gene binding signalling pathways, tumor necrosis factor signalling (15) , interleukin-8 (16) and interleukin-4 (IL-4) (17,18) . Previous research has also revealed a positive association between immune markers and hepatitis B vaccine response, including T-cell receptor β-chain variable (19) , NDRG1-expressing myeloid dendritic cell-2, CDKN1C-expressing myeloid dendritic cell-4 (20) , chemokine (C-X-C motif) ligand 12, https://doi.org/10.1017/S000711452200229X Published online by Cambridge University Press Accepted manuscript interleukin-27 (21) , interferon-γ, interleukin-2 (22) , interleukin-17, interleukin-18 (23) and IL-4 (22,24,25) .…”

Section: Introductionmentioning

confidence: 99%

Folic acid supplementation in pregnant women with hepatitis B surface antigen improves infant hepatitis B surface antibody mediated by infant IL-4

Lian

et al. 2022

Br J Nutr

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Immunoprophylaxis has not completely eliminated hepatitis B virus (HBV) infection due to hyporesponsiveness to hepatitis B vaccine (HepB). We explored the impact of folic acid supplementation (FAS) in pregnant women with positive hepatitis B surface antigen (HBsAg) on their infant hepatitis B surface antibody (anti-HBs) and the mediation effect of infant interleukin-4 (IL-4). We recruited HBsAg-positive mothers and their neonates at baseline. Maternal FAS was obtained via a questionnaire, and neonatal anti-HBs and IL-4 were detected. Follow-up was performed at 11-13 months of age of infants, when anti-HBs and IL-4 were measured. We applied univariate and multivariate analyses. A mediation effect model was performed to explore the mediating role of IL-4. A total of 399 mother–neonate pairs were enrolled and 195 mother–infant pairs were eligible for this analysis. The infant anti-HBs geometric mean concentrations (GMCs) in the maternal FAS group were significnatly higher than those in the no-FAS group [383.8 mIU/ml, 95% confidence interval (CI): 294.2 mIU/ml to 500.7 mIU/ml vs. 217.0 mIU/ml, 95% CI: 147.0 mIU/ml to 320.4 mIU/ml, z=-3.2, P=0.001]. Infants born to women who took folic acid (FA) within the first trimester were more likely to have high anti-HBs titres (adjusted β-value=194.1, P=0.003). The fold change in IL-4 from neonates to infants partially mediated the beneficial influence of maternal FAS on infant anti-HBs (24.7% mediation effect) after adjusting for confounding factors. FAS during the first trimester to HBsAg-positive mothers could facilitate higher anti-HBs levels in infants aged 11-13 months partly by upregulating IL-4 in infants.

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Natural Ingredients to Improve Immunity

et al. 2023

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The immune system protects the body from infectious agents such as bacteria, viruses, or fungi. Once encountered with pathogens or antigens, the innate and adaptive arms of the immune system trigger a strong immune response to eliminate them from the system and protect the body. Thus, well-balanced immunity is pivotal for maintaining human health, as an insufficient level of immune defense leads to infections and tumors. In contrast, the excessive functioning of the immune system causes the development of autoimmune diseases and allergies. Strong immunity requires adequate nutrition, dietary interventions, and sufficient intake of certain vitamins (vitamin C, vitamin D, and folic acid) and minerals (magnesium, zinc, and selenium). Therefore, nutritional and micronutrient deficiencies lead to compromised immunity. Several natural ingredients have shown potent immunomodulatory properties. The immune-enhancing properties of many plants and fungi are due to containing bioactive phytoconstituents such as polyphenols, terpenoids, β-glucans, vitamins, etc. Probiotics and prebiotics can be used as innovative tools to reduce intestinal inflammation and downregulate hypersensitivity reactions. Plant sources of melatonin, a multifunctional molecule with proven anti-inflammatory and immunomodulatory properties, have been discovered relatively recently. The bioactive compounds augment the immune response by directly increasing the cytotoxic activity of natural killer cells, macrophages, and neutrophils. Many phytoconstituents prevent cell damage due to their powerful antimicrobial, antioxidant, and anti-inflammatory properties. The present review attempts to understand the molecular mechanisms underlying the immune-enhancing properties of some bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources.

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Folic acid enhances proinflammatory and antiviral molecular pathways in chicken B-lymphocytes infected with a mild infectious bursal disease virus

Cited by 3 publications

References 70 publications

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

Folic acid supplementation in pregnant women with hepatitis B surface antigen improves infant hepatitis B surface antibody mediated by infant IL-4

Natural Ingredients to Improve Immunity

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