Folic acid functionalized starch encapsulated green synthesized copper oxide nanoparticles for targeted drug delivery in breast cancer therapy

Mariadoss, Arokia Vijaya Anand; Saravanakumar, Kandasamy; Sathiyaseelan, Anbazhagan; Venkatachalam, Karthikkumar; Wang, Myeong‐Hyeon

doi:10.1016/j.ijbiomac.2020.08.036

Cited by 109 publications

(27 citation statements)

References 54 publications

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“…Besides hyaluronic acid and chitosan, other polysaccharides ( e.g. , pullulan [ 43 ], starch [ 155 ], dextran [ 156 ], alginate [ 157 ]) have also gained much attention in developing CR-NDDSs because of their excellent physicochemical properties.…”

Section: Current Development Of Polymeric Materials For Cr-nddss Applicationsmentioning

confidence: 99%

“…Also, the existences of hydroxyl groups in the side chains of the starch off excellent performance in the pharmacological application [ 159 ]. By using aminated starch, negatively charged Helianthus tuberosus—CuO nanoparticles was reversed into positive to improve the cellular internalization of nanoparticles through electrostatic interaction with negatively charged cancerous cell membrane [ 155 ].…”

Section: Current Development Of Polymeric Materials For Cr-nddss Applicationsmentioning

confidence: 99%

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Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing to the unique physicochemical properties, charge-reversal delivery strategy has rapidly developed as a promising approach for drug delivery application, especially for cancer treatment. Charge-reversal nanocarriers are neutral/negatively charged at physiological conditions while could be triggered to positively charged by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) to achieve the prolonged blood circulation and enhanced tumor cellular uptake, thus to potentiate the antitumor effects of delivered therapeutic agents. In this review, we comprehensively summarized the recent advances of charge-reversal nanocarriers, including: (i) the effect of surface charge on cellular uptake; (ii) charge-conversion mechanisms responding to several specific stimuli; (iii) relation between the chemical structure and charge reversal activity; and (iv) polymeric materials that are commonly applied in the charge-reversal delivery systems. Graphical Abstract

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Section: Current Development Of Polymeric Materials For Cr-nddss Applicationsmentioning

confidence: 99%

Section: Current Development Of Polymeric Materials For Cr-nddss Applicationsmentioning

confidence: 99%

Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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“…The ratio changes of ferric to ferrous leads to the responsive MRI that can be used to monitor tumor growth [18]. Using the DCFH-DA fluorescent probe to detect the intracellular ROS level proved that the 4T1 cells were incubated with Fe 3 O 4 -PLGA-Ce6 NPs plus light irradiation had the highest ROS concentration [19]. The results of in vivo and in vitro experiments also strongly support the synergistic treatment of ferroptosis and PDT.…”

Section: Polymer-based Platformsmentioning

confidence: 73%

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

Li¹,

Qiu²

2021

Oncologie

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Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies can selectively kill local tumors without endangering normal tissues. At present, there are more and more researches on optimizing the pharmacological properties of Ce6-based therapeutic agents. Therefore, this review focuses on the properties of Ce6 and the research progress of various nano-scale delivery strategies based on Ce6 in tumor treatment. At last, we summarized the positive impact and bright prospects of Ce6-based nanomaterials in cancer treatment applications.

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“…Specifically, stimuliresponsive delivery systems have been created to target the acidic pH and/or hypoxic environment characteristic of tumor cells [210] (Figure 5). In this respect, polymeric nanoparticles have been investigated as carriers towards various tumor cells, including breast [44,[211][212][213], colon [91,[214][215][216][217], gastric [169,[218][219][220], liver [116,221,222], bladder [46,223], skin [224,225], lung [36,92,226], prostate [94,[227][228][229], and ovarian [230][231][232] cancer cells (Table 2). In this respect, polymeric nanoparticles have been investigated as carriers towards various tumor cells, including breast [44,[211][212][213], colon [91,[214][215][216][217], gastric [169,[218]…”

Section: Drug Deliverymentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Folic acid functionalized starch encapsulated green synthesized copper oxide nanoparticles for targeted drug delivery in breast cancer therapy

Cited by 109 publications

References 54 publications

Charge reversal nano-systems for tumor therapy

Charge reversal nano-systems for tumor therapy

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

Polymer-Based Nanosystems—A Versatile Delivery Approach

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